Preemptive effects of etoricoxib, acetaminophen, nimesulide, and ibuprofen on postoperative pain management after single-implant surgery: a randomized clinical trial

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dc.creatorGustavo Henrique Mattos-Pereira
dc.creatorRafael Paschoal Esteves Lima
dc.creatorLuís Otávio Miranda Cota
dc.creatorRachel Alvarenga-Brant
dc.creatorFernando de Oliveira Costa
dc.date.accessioned2024-09-26T00:05:19Z
dc.date.accessioned2025-09-09T01:19:07Z
dc.date.available2024-09-26T00:05:19Z
dc.date.issued2023
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/clr.14170
dc.identifier.issn1600-0501
dc.identifier.urihttps://hdl.handle.net/1843/76911
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinical Oral Implants Research
dc.rightsAcesso Restrito
dc.subjectPain, postoperative
dc.subjectIbuprofen
dc.subjectAcetaminophen
dc.subject.otherDental implant surgery
dc.subject.otherPostoperative pain
dc.subject.otherPreemptive analgesia
dc.titlePreemptive effects of etoricoxib, acetaminophen, nimesulide, and ibuprofen on postoperative pain management after single-implant surgery: a randomized clinical trial
dc.typeArtigo de periódico
local.citation.epage1308
local.citation.issue11
local.citation.spage1299
local.citation.volume34
local.description.resumoBackground: There is insufficient evidence for pain control in preemptive analgesia (PA) after dental implant surgery, signaling the need for further studies. The objective of this study was to evaluate the efficacy of PA in single dental implant surgeries (SDIS), seeking to identify among the etoricoxib (ETOR), ibuprofen (IBU), nimesulide (NIME), and acetaminophen (ACETA)], which one has the higher efficacy effectiveness in relieving postoperative pain and reducing the use of rescue medication compared to placebo. Methods: In this triple-blind, parallel, randomized controlled clinical trial, 135 individuals with a mean age of 57.6 years (±11.7), both genders, were randomly divided into five groups according to the test drug: I-PLACEBO; II-IBU (600 mg); III-NIME (100 mg); IV-ACETA (750 mg); and V-ETOR (90 mg). The occurrence, duration, and intensity of pain were analyzed using the Chi-square, Fisher's exact and ANOVA tests, and the generalized estimating equation models, when appropriate. Results: Test drugs provided a reduction in postoperative pain scores and lower use of rescue medication when compared to placebo. The ETOR group presented significantly lower pain scores, when compared to other active treatments. The IBU group showed the highest mean number of rescue medication used. Conclusions: All test drugs provided a beneficial preemptive effect demonstrated by the reduced postoperative pain and reduced use of rescue medication. The ETOR group presented lower pain scores, and the IBU group showed the highest mean number of rescue medication used among the test groups.
local.identifier.orcidhttps://orcid.org/0000-0003-0176-0741
local.identifier.orcidhttps://orcid.org/0000-0003-4343-3845
local.identifier.orcidhttps://orcid.org/0000-0003-1517-5842
local.identifier.orcidhttps://orcid.org/0000-0001-9358-2262
local.identifier.orcidhttps://orcid.org/0000-0002-7687-1238
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/clr.14170

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