Associação de estresse oxidativo e obesidade induzida por dieta na secreção de adipocinas

Abstract

ASSOCIATION OF OXIDATIVE STRESS AND DIET-INDUCED OBESITY IN ADIPOKINES SECRETION. Obesity and increased energy intake exert adverse health effects related to oxidative stress. The objective of this study was to evaluate the contribution of a pro-oxidative state and increased adiposity in several characteristic lines of visceral adipose tissue in control animals (C57BL/6) or basal oxidative stress (ApoE-/-). Animals of both strains were divided into subgroups: commercial and high-fat diet. We evaluated oxidative stress, parameters of obesity and adipokines in adipose tissue. It was shown that animals ApoE-/- high-fat diet had higher oxidative stress than the C57BL/6 with the same diet. The parameters of obesity were higher in both strains fed high-fat diet. Inflammatory adipokines were higher in ApoE-/- high-fat diet demonstrating the importance of oxidative stress and associated with obesity in adipose tissue inflammation