Evaluation of the use of tacrolimus ointment for the prevention of hypertrophic scars in experimental model

Página do item simplificado
dc.creatorMariana Campos Souzamenezes
dc.creatorLeonardo de Souza Vasconcellos
dc.creatorCristiana Buzelin Nunes
dc.creatorLuiz Ronaldo Alberti
dc.date.accessioned2023-05-15T20:17:36Z
dc.date.accessioned2025-09-09T00:00:38Z
dc.date.available2023-05-15T20:17:36Z
dc.date.issued2019
dc.format.mimetypepdf
dc.identifier.doi10.1590/abd1806-4841.20197490
dc.identifier.issn18064841
dc.identifier.urihttps://hdl.handle.net/1843/53393
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rightsAcesso Aberto
dc.subjectCicatriz
dc.subjectQuelóide
dc.subjectRatos
dc.subjectPele
dc.subjectTacrolimo
dc.subjectCicatrização
dc.subject.otherScar
dc.subject.otherHypertrophic
dc.subject.otherKeloid
dc.subject.otherSkin
dc.subject.otherTacrolimus
dc.subject.otherWound healing
dc.subject.otherCicatrix
dc.subject.otherInflammation
dc.subject.otherRabbits
dc.titleEvaluation of the use of tacrolimus ointment for the prevention of hypertrophic scars in experimental model
dc.typeArtigo de periódico
local.citation.epage171
local.citation.issue2
local.citation.spage164
local.citation.volume94
local.description.resumoAbstract: Background: Tacrolimus, for its activity on modulation of collagen production and fibroblast activity, may have a role in the prevention of hypertrophic scars. Objectives: Evaluate macroscopic, microscopic, metabolic, laboratory effects and side effects of the use of topical tacrolimus ointment, in different concentrations, in the prevention of hypertrophic scars. Methods: Twenty-two rabbits were submitted to the excision of 2 fragments of 1 cm of each ear, 4 cm apart, down to cartilage. The left ear of the animals was standardized as control and Vaseline applied twice a day. The right ear received tacrolimus ointment, at concentrations of 0.1% on the upper wound and 0.03% on the lower wound, also applied twice a day. Macroscopic, microscopic, laboratory criteria and the animals’ weight were evaluated after 30 days of the experiment. Results: Wounds treated with tacrolimus, at concentrations of 0.1% and 0.03%, when compared to control, showed a lower average degree of thickening (p = 0.048 and p <0.001, respectively). The average of scar thickness and lymphocyte, neutrophil and eosinophil concentrations are lower in the treated wounds compared to the control (p <0.001, p=0.022, p=0.007, p=0.044, respectively). The mean concentration of lymphocytes is lower in wounds treated with a higher concentration of the drug (p=0.01). Study Limitations: experiment lasted only 30 days. Conclusions: Tacrolimus at the 2 concentrations evaluated reduced the severity of inflammatory changes and positively altered the macroscopic aspect of the scar in the short term. Its use was shown to be safe, with no evidence of systemic or local adverse effects.
local.identifier.orcidhttps://orcid.org/0000-0002-5266-6870
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://doi:10.1590/abd1806-4841.20197490

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Evaluation of the use of tacrolimus ointment for the prevention of hypertrophic scars in experimental model pdfa.pdf
Tamanho:
358.93 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG