Kallikrein 4 and matrix metalloproteinase-20 immunoexpression in malignant, benign and infiltrative odontogenic tumors

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dc.creatorMarcelo Macedo Crivelini
dc.creatorDenise Tostes Oliveira
dc.creatorRicardo Alves de Mesquita
dc.creatorSuzana Cantanhede Orsini Machado de Sousa
dc.creatorAdriano Motta Loyola
dc.date.accessioned2024-10-02T23:48:47Z
dc.date.accessioned2025-09-08T22:59:50Z
dc.date.available2024-10-02T23:48:47Z
dc.date.issued2016
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.4103%2F0973-029X.185927
dc.identifier.issn1998-393X
dc.identifier.urihttps://hdl.handle.net/1843/77151
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral and Maxillofacial Pathology
dc.rightsAcesso Aberto
dc.subjectMatrix metalloproteinase 20
dc.subjectOdontogenic tumors
dc.subjectKallikreins
dc.subjectGene expression
dc.subjectNeoplasms
dc.subjectImmunohistochemistry
dc.subjectBiology
dc.subject.otherOdontogenic tumors
dc.subject.otherMMP-20
dc.subject.otherKLK 4
dc.titleKallikrein 4 and matrix metalloproteinase-20 immunoexpression in malignant, benign and infiltrative odontogenic tumors
dc.typeArtigo de periódico
local.citation.epage251
local.citation.issue2
local.citation.spage246
local.citation.volume20
local.description.resumoContext: Matrix metalloproteinase-20 (MMP20) (enamelysin) and kallikrein 4 (KLK4) are enzymes secreted by ameloblasts that play an important role in enamel matrix degradation during amelogenesis. However, studies have shown that neoplastic cells can produce such enzymes, which may affect the tumor infiltrative and metastatic behaviors. Aims: The aim of this study is to assess the biological role of MMP20 and KLK4 in odontogenic tumors. Materials and methods: The enzymes were analyzed immunohistochemically in ameloblastoma, adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor, keratocystic odontogenic tumor with or without recurrence and odontogenic carcinoma. Statistical analysis used: Clinicopathological parameters were statistically correlated with protein expression using the Fisher's exact test. Kruskal-Wallis and Wilcoxon-independent methods were used to evaluate the differences in median values. Results: Positive Immunoexpression was detected in all benign lesions, with a prevalence of 75-100% immunolabeled cells. Patients were predominantly young, Caucasian, female, with slow-growing tumors located in the mandible causing asymptomatic swelling. No KLK4 expression was seen in carcinomas, and the amount of MMP20-positive cells varied between 20% and 80%. Rapid evolution, recurrence and age >60 years characterized the malignant nature of these lesions. Conclusions: Data showed that KLK4 and MMP20 enzymes may not be crucial to tumoral infiltrative capacity, especially in malignant tumors, considering the diversity and peculiarity of these lesions. The significant immunoexpression in benign lesions, remarkably in AOT, is likely associated with differentiated tumor cells that can produce and degrade enamel matrix-like substances. This would be expected since the histogenesis of odontogenic tumors commonly comes from epithelium that recently performed a secretory activity in tooth formation.
local.identifier.orcidhttps://orcid.org/0000-0003-3207-4007
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://journals.lww.com/jpat/toc/2016/20020

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