18F-FDG PET/CT as a prognostic factor in penile cancer

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dc.creatorAndrésalazar
dc.creatorEduardo Paulino Júnior
dc.creatorPaulo Guilherme o. Salles
dc.creatorRaul Silva Filho
dc.creatorEdna a. Reis
dc.creatorMarcelo Mamede
dc.date.accessioned2023-06-19T20:06:23Z
dc.date.accessioned2025-09-08T23:47:11Z
dc.date.available2023-06-19T20:06:23Z
dc.date.issued2018-08-24
dc.format.mimetypepdf
dc.identifier.doi10.1007/s00259-018-4128-7
dc.identifier.issn16197070
dc.identifier.urihttps://hdl.handle.net/1843/55125
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEuropean Journal of Nuclear Medicine and Molecular Imaging
dc.rightsAcesso Aberto
dc.subjectTomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
dc.subjectNeoplasias Penianas
dc.subjectPrognóstico
dc.subjectAnálise de Sobrevida
dc.subject.otherPET/CT
dc.subject.otherPenile cancer
dc.subject.otherPrognostic value
dc.subject.otherSurvival
dc.title18F-FDG PET/CT as a prognostic factor in penile cancer
dc.typeArtigo de periódico
local.citation.epage863
local.citation.issue4
local.citation.spage855
local.citation.volume46
local.description.resumoPurpose Penile cancer (PC) is a rare neoplasm with an aggressive behavior and variable prognosis. Lymph node (LN) involvement and pathological features of the primary lesion have been proven to be the most important survival factors. Positron emission tomography/computed tomography with fluorodeoxyglucose labelled with fluorine-18 (18F-FDG PET/CT) provides information on tumor staging and works as a prognostic factor, with promising results in other carcinomas.The aim of the present study is to evaluate PET/CT as a prognostic factor in PC. Methods Fifty-five patients (mean age 56.6 y) diagnosed with penile squamous cell carcinoma were prospectively evaluated from 2012 to 2014. All subjects underwent 18F-FDG PET/CT before treatment and were regularly followed after surgery. Results Out of the 53 patients selected, 17 (32.1%) had localized disease (cT1–2) and 24 (45.3%) had palpable nodes (cN+). Partial penile amputation was performed in 38 patients (71.7%) and inguinal lymphadenectomy (LND) in 30 (56.6%). From the LND group, 16 (53.3%) presented with positive neoplastic cells (pN+). Patients with more aggressive disease had a significantly (p = 0.019) higher 18F-FDG tumor uptake (pSUVmax), while inguinal LN uptake (nSUVmax) was able to recognize metastatic LN (p = 0.039). Some pathological prognostic features, when presented, have shown significant changes in pSUVmax values. Receiver operating characteristic (ROC) curves were performed and specific cutoff values of pSUVmax were evaluated to determine sensitivity and specificity. Regarding regional LNs, PET/CT presented a 76.2% accuracy in cN+ patients. After a 39-month follow up, pSUVmax of 16.6 (p = 0.0001) and nSUVmax of 6.5 (p = 0.019) were established as the ideal values to predict cancer-specific survival. The multivariate analysis confirmed nSUVmax as a predictor for LN metastasis (p = 0.043) and pSUVmax as a mean to estimate survival rate (p = 0.05). Conclusion This study showed promising results on the use of 18F-FDG PET/CT as a prognostic tool for PC, using specific cut off values of pSUVmax and nSUVmax.
local.identifier.orcidhttps://orcid.org/0000-0001-6157-6511
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE ESTATÍSTICA
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA E IMAGEM
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s00259-018-4128-7

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