Clinical response to donepezil in mild and moderate dementia: relationship to drug plasma concentration and CYP2D6 and APOE genetic polymorphisms

Página do item simplificado
dc.creatorLuís Felipe José Ravic de Miranda
dc.creatorKarina Braga Gomes Borges
dc.creatorPedro Augusto Lopes Tito
dc.creatorJosianne Nicácio Silveira
dc.creatorGerson Antônio Pianetti
dc.creatorRicardo Martins Duarte Byrro
dc.creatorPatrícia Regina Henrique Peles
dc.creatorFernando Henrique Pereira
dc.creatorThiago Rezende dos Santos
dc.creatorArthur Goncalves Assini
dc.creatorValéria Valadares Ribeiro
dc.creatorEdgar Nunes de Moares
dc.creatorPaulo Caramelli
dc.date.accessioned2022-03-16T18:30:32Z
dc.date.accessioned2025-09-08T23:42:43Z
dc.date.available2022-03-16T18:30:32Z
dc.date.issued2017
dc.identifier.doi10.3233/JAD-160164
dc.identifier.issn1875-8908
dc.identifier.urihttps://hdl.handle.net/1843/40162
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Alzheimer's Disease
dc.rightsAcesso Restrito
dc.subjectDoença de Alzheimer
dc.subjectDemência
dc.subjectApolipoproteínas E
dc.subjectCitocromo P-450 CYP2D6
dc.subjectDonepezila
dc.subjectGenética
dc.subject.otherAlzheimer’s disease
dc.subject.otherAPOE
dc.subject.otherCYP2D6
dc.subject.otherDonepezil
dc.subject.otherGenetics
dc.subject.otherNaturalistic study
dc.titleClinical response to donepezil in mild and moderate dementia: relationship to drug plasma concentration and CYP2D6 and APOE genetic polymorphisms
dc.typeArtigo de periódico
local.citation.epage549
local.citation.issue2
local.citation.spage539
local.citation.volume55
local.description.resumoThe clinical response to donepezil in patients with mild and moderate dementia was investigated in relation to the drug plasma concentration and APOE and CYP2D6 polymorphisms. In a prospective naturalistic observational study, 42 patients with Alzheimer’s disease (AD) and AD with cerebrovascular disease who took donepezil (10 mg) for 12 months were evaluated. Their DNA was genotyped, and the donepezil plasma concentrations were measured after 3, 6, and 12 months. Good responders scored ≥–1 on the Mini-Mental State Examination at 12 months in comparison to the baseline score. The study results indicated the good response pattern was influenced by the concentration of donepezil, but not by APOE and CYP2D6 polymorphisms.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE ESTATÍSTICA
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA E IMAGEM
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad160164

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG