A reanalysis of cognitive-functional performance in older adults: investigating the interaction between normal aging, mild cognitive impairment, mild alzheimer's disease dementia, and depression

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dc.creatorJonas Jardim de Paula
dc.creatorMaria Aparecida Camargos Bicalho
dc.creatorRafaela Ávila
dc.creatorMarco Túlio Gualberto Cintra
dc.creatorBreno Satler Diniz
dc.creatorLeandro Fernandes Malloy Diniz
dc.date.accessioned2023-08-07T19:35:26Z
dc.date.accessioned2025-09-09T01:31:54Z
dc.date.available2023-08-07T19:35:26Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.issn1664-1078
dc.identifier.urihttps://hdl.handle.net/1843/57564
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Psychology
dc.rightsAcesso Aberto
dc.subjectIdoso Fragilizado
dc.subjectTestes de Estado Mental e Demência
dc.subjectDisfunção Cognitiva
dc.subjectDepressão
dc.subjectAtividades Cotidianas
dc.subjectDoença de Alzhmeier
dc.subject.otherOlder adults
dc.subject.otherdepression
dc.subject.otherCognitive assessment
dc.subject.otherActivities of daily living
dc.subject.otherMild Cognitive Impairment
dc.subject.otherAlzheimer Disease
dc.titleA reanalysis of cognitive-functional performance in older adults: investigating the interaction between normal aging, mild cognitive impairment, mild alzheimer's disease dementia, and depression
dc.typeArtigo de periódico
local.citation.epage11
local.citation.issue2061
local.citation.spage1
local.citation.volume6
local.description.resumoDepressive symptoms are associated with cognitive-functional impairment in normal aging older adults (NA). However, less is known about this effect on people with mild Cognitive Impairment (MCI) and mild Alzheimer’s disease dementia (AD). We investigated this relationship along with the NA-MCI-AD continuum by reanalyzing a previously published dataset. Participants (N = 274) underwent comprehensive neuropsychological assessment including measures of Executive Function, Language/Semantic Memory, Episodic Memory, Visuospatial Abilities, Activities of Daily Living (ADL), and the Geriatric Depression Scale. MANOVA,logistic regression and chi-square tests were performed to assess the association between depression and cognitive-functional performance in each group. In the NA group, depressed participants had a lower performance compared to non-depressed participants in all cognitive and functional domains. However, the same pattern was not observed in the MCI group or in AD. The results suggest a progressive loss of association between depression and worse cognitive-functional performance along the NA-MCI-ADcontinuum
local.identifier.orcidhttps://orcid.org/0000-0003-3089-655X
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727063/pdf/fpsyg-06-02061.pdf

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