Hemostasis and oxidative stress in chronic kidney disease in children and adolescents

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dc.creatorAna Cristina dos Santos Lopes
dc.creatorLetícia Parreira Nunes Sousa
dc.creatorRívia Mara Morais e Silva
dc.creatorAna Cristina Simões e Silva
dc.creatorLuci Maria Sant`ana Dusse
dc.creatorPatrícia Nessralla Alpoim
dc.date.accessioned2024-11-26T23:26:23Z
dc.date.accessioned2025-09-09T01:30:06Z
dc.date.available2024-11-26T23:26:23Z
dc.date.issued2022-08-31
dc.identifier.doi10.1139/cjpp-2021-0714
dc.identifier.issn0008-4212
dc.identifier.urihttps://hdl.handle.net/1843/78303
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCanadian Journal of Physiology and Pharmacology
dc.rightsAcesso Restrito
dc.subjectMedicina
dc.subjectDoença renal crônica
dc.subject.otherDoença renal crônica
dc.subject.otherHemostasia
dc.subject.otherEstresse oxidativo
dc.subject.otherCriança
dc.subject.otherAdolescentes
dc.titleHemostasis and oxidative stress in chronic kidney disease in children and adolescents
dc.typeArtigo de periódico
local.citation.epage936
local.citation.issue9
local.citation.spage926
local.citation.volume100
local.description.resumoChronic kidney disease (CKD) can be defined as the progressive loss of renal function, characterized by a decreased glomerular filtration rate (GFR). The etiology of CKD in childhood is mainly associated with congenital anomalies of the kidneys and urinary tract (CAKUT) and with glomerular diseases. The goal of this study was to investigate the hemostasis and oxidative stress in pediatric CKD of different etiologies. Fifty-four CKD children and adolescents and 52 controls were enrolled in this study. The evaluation of hemostasis was carried out by determination of D-dimer (D-Di) and plasminogen activator inhibitor (PAI-1) plasma levels, while oxidative stress was evaluated by thiobarbituric acid reactive substance (TBARS) levels, protein carbonyl content, plasma antioxidant capacity (MTT), and ascorbate. The D-Di was increased in CAKUT stage 3 or 4 patients compared with those with glomerular disease. PAI-1 was increased in patients with glomerular disease compared with CAKUT. Carbonyl protein content was higher in the control group compared with glomerular disease stage 3 or 4 patients. Our findings showed that the reduction in GFR is associated with a state of hypercoagulability. The analysis of integrated networks showed an expansion of connections among hemostatic and oxidative stress markers in CKD children and adolescents compared with controls.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://cdnsciencepub.com/doi/full/10.1139/cjpp-2021-0714

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