Inactivated alpha toxin from Clostridium novyi type B in nano-emulsion protect partially protects Swiss mice from lethal alpha toxin challenge

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dc.creatorMellanie Karoline do Carmo Félix
dc.creatorTúllio Teixeira Deusdará
dc.creatorLucas Samuel Soares dos Santos
dc.creatorRaimundo Wagner de Souza Aguiar
dc.creatorRoberto Franco Teixeira Corrêa
dc.creatorIgor Viana Brandi
dc.creatorEliane Macedo Sobrinho
dc.creatorBergmann Morais Ribeiro
dc.creatorLuis André Morais Mariúba
dc.creatorPaulo Afonso Nogueira
dc.creatorKattyanne Souza Costa
dc.creatorKelvinson Fernandes Viana
dc.creatorAlex Sander Rodrigues Cangussu
dc.date.accessioned2022-12-13T15:00:51Z
dc.date.accessioned2025-09-09T00:09:49Z
dc.date.available2022-12-13T15:00:51Z
dc.date.issued2019-10-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.identifier.doi10.1038/s41598-019-50683-2
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1843/47905
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.subjectAdjuvantes imunológicos
dc.subjectClostridium
dc.subjectAntígenos
dc.titleInactivated alpha toxin from Clostridium novyi type B in nano-emulsion protect partially protects Swiss mice from lethal alpha toxin challenge
dc.typeArtigo de periódico
local.citation.spage14082
local.citation.volume9
local.description.resumoNano-emulsions are promising carriers for antigen delivery. Here, we evaluated the efficacy of a water-oil nano-emulsion containing concentrated, inactivated Clostridium novyi (C. novyi) type B supernatant culture (nano-iCnB) in protecting Swiss mice against a lethal dose of alpha toxin concentrated extract. Proteins were confirmed in the nano-iCnB and their stabilities were determined according physical parameters such as Zeta Potential (ZP). Biochemical, hematological parameters and morphological appearance of liver, spleen and thigh muscle alterations were examined to determine the safety of the compound. Partial protection against lethal doses was achieved in immunized mice despite low IgG titers. These data suggest that our nano-emulsion is a simple and efficient method of promoting antigen delivery for toxin-related diseases.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773766/

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