Treatments for burning mouth syndrome: a network meta-analysis

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dc.creatorRaquel Alvarenga Brant
dc.creatorFernando de Oliveira Costa
dc.creatorGustavo Henrique Mattos Pereira
dc.creatorRafael Paschoal Esteves Lima
dc.creatorFernanda Vieira Belém
dc.creatorLai Honghao
dc.creatorLong Ge
dc.creatorRicardo Santiago Gomez
dc.creatorCarolina Castro Martins
dc.date.accessioned2025-02-24T19:51:02Z
dc.date.accessioned2025-09-09T00:43:28Z
dc.date.available2025-02-24T19:51:02Z
dc.date.issued2023-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1177/00220345221130025
dc.identifier.issn1544-0591
dc.identifier.urihttps://hdl.handle.net/1843/80385
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Dental Research
dc.rightsAcesso Restrito
dc.subjectAnti-anxiety agents
dc.subjectClonazepam
dc.subjectMouth diseases
dc.subjectPsychophysiologic disorders
dc.subjectStomatognathic diseases
dc.subjectNetwork meta-analysis
dc.subject.otherAnti-anxiety agents
dc.subject.otherClonazepam
dc.subject.otherInterventional studies
dc.subject.otherPsychophysiologic disorders
dc.subject.otherMouth diseases
dc.subject.otherStomatognathic diseases
dc.titleTreatments for burning mouth syndrome: a network meta-analysis
dc.typeArtigo de periódico
local.citation.epage145
local.citation.issue2
local.citation.spage135
local.citation.volume102
local.description.resumoThe aim of this systematic review and network meta-analysis (NMA) of randomized controlled trials was to evaluate the effectiveness of treatments for pain relief of burning mouth syndrome (BMS). Five databases and gray literature were searched. Independent reviewers selected studies, extracted data, and assessed the risk of bias. The primary outcome was pain relief or burning sensation, and the secondary outcomes were side effects, quality of life, salivary flow, and TNF-α and interleukin 6 levels. Four comparable interventions were grouped into different network geometries to ensure the transitivity assumption for pain: photobiomodulation therapy, alpha-lipoic acid, phytotherapics, and anxiolytics/antidepressants. Mean difference (MD) and 95% CI were calculated for continuous outcomes. The minimal important difference to consider a therapy beneficial against placebo was an MD of at least -1 for relief of pain. To interpret the results, the GRADE approach for NMA was used with a minimally contextualized framework and the magnitude of the effect. Forty-four trials were included (24 in the NMA). The anxiolytic (clonazepam) probably reduces the pain of BMS when compared with placebo (MD, -1.88; 95% CI, -2.61 to -1.16; moderate certainty). Photobiomodulation therapy (MD, -1.90; 95% CI, -3.58 to -0.21) and pregabalin (MD, -2.40; 95% CI, -3.49 to -1.32) achieved the minimal important difference of a beneficial effect with low or very low certainty. Among all tested treatments, only clonazepam is likely to reduce the pain of BMS when compared with placebo. The majority of the other treatments had low and very low certainty, mainly due to imprecision, indirectness, and intransitivity. More randomized controlled trials comparing treatments against placebo are encouraged to confirm the evidence and test possible alternative treatments (PROSPERO CRD42021255039).
local.identifier.orcidhttps://orcid.org/0000-0001-9358-2262
local.identifier.orcidhttps://orcid.org/0000-0002-7687-1238
local.identifier.orcidhttps://orcid.org/0000-0003-0176-0741
local.identifier.orcidhttps://orcid.org/0000-0003-4343-3845
local.identifier.orcidhttps://orcid.org/0000-0003-1746-2685
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0001-9072-3226
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://journals.sagepub.com/doi/10.1177/00220345221130025?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

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