Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study

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dc.creatorRafael Coelho Magalhães
dc.creatorJanaina Matos Moreira
dc.creatorÉrica Leandro Marciano Vieira
dc.creatorNatália Pessoa Rocha
dc.creatorDébora Marques Miranda
dc.creatorAna Cristina Simões e Silva
dc.date.accessioned2023-07-18T20:19:43Z
dc.date.accessioned2025-09-08T23:32:18Z
dc.date.available2023-07-18T20:19:43Z
dc.date.issued2017-05-02
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1155/2017/8201423
dc.identifier.issn0962-9351
dc.identifier.urihttps://hdl.handle.net/1843/56633
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMediators of Inflammation
dc.rightsAcesso Aberto
dc.subjectRecém-Nascido
dc.subjectUrina
dc.subject.otherRecém-Nascido
dc.subject.otherUrina
dc.titleUrinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study
dc.typeArtigo de periódico
local.citation.epage12
local.citation.spage1
local.citation.volume2017
local.description.resumoObjectives. To evaluate the association between inflammatory biomarkers, neurotrophic factors, birth conditions, and the presence of motor development abnormalities in preterm neonates. Methods. Plasma and urinary levels of cytokines (IL-1β, IL-6, IL-10, TNF, and IL-12p70), chemokines (CXCL8/IL-8, CCL2/MCP-1, CCL5/RANTES, CXCL10/IP-10, and CXCL9/MIG), and neurotrophic factors (BDNF and GDNF) were evaluated in 40 preterm neonates born between 28 and 32 incomplete weeks of gestation, at four distinct time points: at birth (umbilical cord blood) (T0), at 48 (T1), at 72 hours (T2), and at 3 weeks after birth (T3). Biomarkers levels were compared between different time points and then associated with Test of Infant Motor Performance (TIMP) percentiles. Results. Maternal age, plasma, and urinary concentrations of inflammatory molecules and neurotrophic factors were significantly different between groups with normal versus lower than expected motor development. Higher levels of GDNF were found in the group with lower than expected motor development, while IL-1β and CXCL8/IL-8 values were higher in the group with typical motor development. Conclusion. Measurements of cytokines and neurotrophic factors in spot urine may be useful in the follow-up of motor development in preterm neonates.
local.identifier.orcidhttp://orcid.org/0000-0002-4147-5614
local.identifier.orcidhttp://orcid.org/0000-0003-2616-8082
local.identifier.orcidhttp://orcid.org/0000-0001-9222-3882
local.identifier.orcidhttps://orcid.org/0000-0002-7081-8401
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE TERAPIA OCUPACIONAL
local.publisher.departmentEEFFTO - ESCOLA DE EDUCAÇÃO FISICA, FISIOTERAPIA E TERAPIA OCUPACIONAL
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://www.hindawi.com/journals/mi/2017/8201423/

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