Expression of FGF-2/FGFR-1 in normal mucosa, salivary gland, preneoplastic, and neoplastic lesions of the oral cavity

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dc.creatorBruno Mariz
dc.creatorCiro Dantas Soares
dc.creatorThayna Melo de Lima Morais
dc.creatorFelipe Paiva Fonseca
dc.creatorMaria Goreti Carvalho
dc.creatorJacks Jorge Junior
dc.date.accessioned2023-10-30T18:06:13Z
dc.date.accessioned2025-09-08T22:53:55Z
dc.date.available2023-10-30T18:06:13Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.1111/jop.12773
dc.identifier.issn09042512
dc.identifier.urihttps://hdl.handle.net/1843/60254
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectFibroblast growth factors
dc.subjectProtein-Tyrosine Kinases
dc.subjectFibroblast growth factor 2
dc.subjectFibroblast growth factor 1
dc.subjectProteins
dc.subjectCarcinoma
dc.subjectMouth neoplasms
dc.subject.otheracesso restrito assunto Fibroblast Growth Factor 2 fao clinica busca dia 15 do 09 2023 assunto
dc.titleExpression of FGF-2/FGFR-1 in normal mucosa, salivary gland, preneoplastic, and neoplastic lesions of the oral cavity
dc.typeArtigo de periódico
local.citation.epage822
local.citation.issue9
local.citation.spage816
local.citation.volume47
local.description.resumoFibroblast growth factor 2 (FGF-2) is a multifunctional cytokine expressed in several tissues and involved in a wide variety of biologic activities, with one low molecular weight (LMW) protein present in the cytosol, which is secreted, acting via its receptors (FGFRs), and four high molecular weight (HMW) proteins located in the nucleus. Fibroblast growth factor receptor (FGFR) family has four (FGFR1-4) transmembrane tyrosine kinase receptors expressed on several cell types, and FGFR-1 has been indicated as a potential molecular target in several types of cancer, including oral squamous cell carcinoma (OSCC). The FGF-2/FGFR-1 expression has been studied in the oral cavity, and it was associated with the wound repair process, the development of benign and malignant salivary gland tumors, besides being related to oral potentially malignant disorders (OPMDs) and OSCC. Hence, we critically review the currently available data on FGF-2/FGFR-1 expression in the normal mucosa and lesions of the oral cavity
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12773

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