Diabetes mellitus: the linkage between oxidative stress, inflammation, hypercoagulability and vascular complications

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dc.creatorCaroline Pereira Domingueti
dc.creatorLuci Maria SantAna Dusse
dc.creatorMaria das Graças Carvalho
dc.creatorLirlândia Pires de Sousa
dc.creatorKarina Braga Gomes Borges
dc.creatorAna Paula Salles Moura Fernandes
dc.date.accessioned2022-03-16T20:43:57Z
dc.date.accessioned2025-09-09T00:00:54Z
dc.date.available2022-03-16T20:43:57Z
dc.date.issued2016
dc.identifier.doihttps://doi.org/10.1016/j.jdiacomp.2015.12.018
dc.identifier.issn1056-8727
dc.identifier.urihttps://hdl.handle.net/1843/40167
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Diabetes and its Complications
dc.rightsAcesso Restrito
dc.subjectDiabetes mellitus
dc.subjectAngiopatias diabéticas
dc.subjectTrombofilia
dc.subjectEstresse oxidativo
dc.subjectInflamação
dc.subject.otherDiabetes mellitus
dc.subject.otherVascular complications
dc.subject.otherEndothelial dysfunction
dc.subject.otherHypercoagulability
dc.subject.otherInflammation
dc.titleDiabetes mellitus: the linkage between oxidative stress, inflammation, hypercoagulability and vascular complications
dc.typeArtigo de periódico
local.citation.epage745
local.citation.issue4
local.citation.spage738
local.citation.volume30
local.description.resumoBackground: Vascular complications are the leading cause of morbidity and mortality among patients with type 1 and type 2 diabetes mellitus. These vascular abnormalities result of a chronic hyperglycemic state, which leads to an increase in oxidative stress and inflammatory responses. Aim: This review addresses the relationships among endothelial dysfunction, hypercoagulability and inflammation and their biomarkers in the development of vascular complications in type 1 and type 2 diabetes. Results: Inflammation, endothelial dysfunction, and hypercoagulability are correlated to each other, playing an important role in the development of vascular complications in diabetic patients. Moreover, it has been observed that several endothelial, inflammatory and pro-coagulant biomarkers, such as VWF, IL-6, TNF-α, D-dimer and PAI-1, are increased in diabetic patients who have microvascular and macrovascular complications, including nephropathy or cardiovascular disease. Conclusion: It is promising the clinical and laboratory use of endothelial, inflammatory and pro-coagulant biomarkers for predicting the risk of cardiovascular and renal complications in diabetic patients and for monitoring these patients.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S1056872715005073#ab0005

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