Relação da sarcopenia com a incapacidade funcional em idosos portadores da Doença de Alzheimer: revisão de literatura

Abstract

Aging is considered biological, psychological and social phenomenon, that affects human and its relationship with the world and its own history. The increase in the proportion of the elderly in the population is a worldwide phenomenon, which has been called the "demographic revolution”. Sarcopenia is a syndrome characterized by generalized progressive loss of skeletal muscle mass and strength with risk of adverse outcomes, such as physical disability, poor quality of life and death. This study aims to perform a literature review to verify the relationship between sarcopenia and functional disability in elderly people with Alzheimer's disease (AD). Six studies were included in the study, with samples ranging from 67 to 265 elderly, all using comparison groups "with dementia" and "without dementia", with participation of both sexes.The age of participants ranged from 65 to 84 years. This review of the literature has shown that patients with sarcopenia have shown a significant tendency to present disability in their daily life activities in the early stages of AD. There are common underlying conditions shared by sarcopenia and AD, such as inflammation, oxidative stress, nutrition, immobility, and hormonal dysregulation. In conclusion, the present study demonstrated that sarcopenia is associated with functional impairment in the elderly with Alzheimer's Disease, from the initial stage of the disease.