Presence of osteocalcin, osteopontin, and reactive oxygen species-positive cells in pulp tissue after dental bleaching

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dc.creatorFrancine Benetti
dc.creatorAndré Luiz Fraga Briso
dc.creatorMarina Carminatti
dc.creatorde Araújo Lopes
dc.creatorBarbosa
dc.creatorEdilson Ervolino
dc.creatorJoão Eduardo Gomes Filho
dc.creatorLuciano Tavares Angelo Cintra
dc.date.accessioned2022-09-28T23:08:23Z
dc.date.accessioned2025-09-08T22:51:52Z
dc.date.available2022-09-28T23:08:23Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/iej.13049
dc.identifier.issn01432885
dc.identifier.urihttps://hdl.handle.net/1843/45699
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Endodontic Journal
dc.rightsAcesso Restrito
dc.subjectHydrogen peroxide
dc.subjectOsteocalcin
dc.subjectOsteopontin
dc.subjectAntibodies
dc.subjectInflammation
dc.subject.otherDental pulp
dc.subject.otherHydrogen peroxide
dc.subject.otherOsteocalcin
dc.subject.otherOsteopontin
dc.subject.otherReactive oxygen species
dc.subject.otherTertiary dentine
dc.titlePresence of osteocalcin, osteopontin, and reactive oxygen species-positive cells in pulp tissue after dental bleaching
dc.typeArtigo de periódico
local.citation.epage675
local.citation.issue05
local.citation.spage665
local.citation.volume52
local.description.resumoAim: To analyse the influence of H2 O2 on pulp repair through osteocalcin and osteopontin immunolabelling and in cellular defence by using the antireactive oxygen species (ROS) antibody. Methodology: The maxillary molars of 50 rats were treated with 35% H2 O2 (Ble groups) or placebo gel (control groups). At 0 h and 2, 7, 15 and 30 days (n = 10 hemimaxillae), the rats were killed and pulp tissue was evaluated using inflammation and immunolabelling scores (osteocalcin/osteopontin); ROS-positive cells were counted. Paired t-test and Wilcoxon signed-rank test were used (P < 0.05). Results: The Ble group had necrosis in the coronal pulp at 0 h and in the occlusal third of the coronal pulp at 2 days; at 7, 15 and 30 days, no inflammation was noted similar to the controls (P > 0.05). Osteocalcin was absent in the Ble at 0 h, moderate at 2 days and increased thereafter, differing from the controls at all two periods (P < 0.05). Osteopontin was higher principally at 7 and 15 days in Ble groups, but differing with control groups from 2 days after bleaching (P < 0.05). The Ble group had more ROS-positive cells in the pulp at 7 and 15 days (P < 0.05). Tertiary dentine was observed at 7 days, increasing thereafter (P < 0.05). Conclusions: Post-bleaching pulp repair was associated with increased osteocalcin over time. Osteopontin also participated in this process, and anti-ROS was involved in cellular defence against H2 O2 .
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/iej.13049

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