Can morphological features evaluated in oral cancer biopsies influence in decision-making? a preliminary study

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dc.creatorCamila Ferreira Leite
dc.creatorKarine Duarte da Silva
dc.creatorMartinho Campolina Rebello Horta
dc.creatorMaria Cássia Ferreira de Aguiar
dc.date.accessioned2024-08-13T21:59:51Z
dc.date.accessioned2025-09-09T01:18:25Z
dc.date.available2024-08-13T21:59:51Z
dc.date.issued2020
dc.identifier.doihttps://doi.org/10.1016/j.prp.2020.153138
dc.identifier.issn1618-0631
dc.identifier.urihttps://hdl.handle.net/1843/73935
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPathology Research and Practice
dc.rightsAcesso Restrito
dc.subjectImmunohistochemistry
dc.subjectMouth
dc.subjectCarcinoma, squamous cell
dc.subjectPrognosis
dc.subjectBiopsy
dc.subjectAssociation
dc.subjectTongue
dc.subjectEvaluation study
dc.subjectNeoplasms
dc.subject.otherImmunohistochemistry
dc.subject.otherMouth
dc.subject.otherSquamous cell carcinoma
dc.subject.otherTumor budding
dc.titleCan morphological features evaluated in oral cancer biopsies influence in decision-making? a preliminary study
dc.typeArtigo de periódico
local.citation.epage153138
local.citation.issue10
local.citation.spage153138
local.citation.volume216 Pathology research and practice :
local.description.resumoTumor budding (TB) is a promising prognostic marker in many cancers including oral squamous cell carcinoma. The evaluation of TB in preoperative diagnostic biopsies has been proven be possible; therefore, the association of TB with other morphological features can represent an important aid in the previous treatment decision. This study aims to evaluate TB in oral squamous cell carcinoma (OSCC) biopsies, assessing its association with other morphological characteristics of the sample. A total of 56 cases of OSCC were investigated. In hematoxylin and eosin-stained slides, morphological features including histopathological grading and mode of invasion were evaluated in the deep invasive front. Moreover, immunohistochemistry was performed with anti-multi-cytokeratin antibody helping in the identification of TB, which was graded as low-intensity or no TB and high-intensity TB. Descriptive and bivariate analyses were performed, and the level of significance was set at 5%. The tongue was the most-affected site with 29 (51.7 %) tumors. The predominant mode of invasion (27-48.2 %) was by groups of neoplastic cells without clear boundaries. Of the cases investigated, 37 (66.1 %) were high-intensity TB, which was associated with the mode of invasion of the tumors (p < 0.05). All cases with the worst mode of invasion showed high-intensity TB. Preliminary results showed the potential of morphological features, such as TB and mode of invasion, evaluated in diagnostic specimens of OSCC, aiding in the treatment decision to select patients who could benefit from more-aggressive treatments.
local.identifier.orcidhttps://orcid.org/0000-0001-9273-376X
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0344033820319932?via%3Dihub

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