Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil

Página do item simplificado
dc.creatorNuno Faria
dc.creatorJohn McCrone
dc.creatorRuben Hulswit
dc.creatorLucas Franco
dc.creatorMariana Ramundo
dc.creatorJaqueline de Jesus
dc.creatorPamela. Andrade
dc.creatorThais Coletti
dc.creatorGiulia Ferreira
dc.creatorCamila Silva
dc.creatorErika Manuli
dc.creatorThomas Mellan
dc.creatorRafael Pereira
dc.creatorPedro Peixoto
dc.creatorMoritz Kraemer
dc.creatorNelson Gaburo
dc.creatorCecilia da Camilo
dc.creatorHenrique Hoeltgebaum
dc.creatorWilliam Souza
dc.creatorEsmenia Rocha
dc.creatorLeandro de Souza
dc.creatorMariana de Pinho
dc.creatorCharles Whittaker
dc.creatorLeonardo Araujo
dc.creatorFrederico Malta
dc.creatorAline de Lima
dc.creatorJoice do Silva
dc.creatorDanielle Zauli
dc.creatorAlessandro de Ferreira
dc.creatorRicardo Schnekenberg
dc.creatorDaniel Laydon
dc.creatorPatrick Walker
dc.creatorHannah Schlüter
dc.creatorIngra Claro
dc.creatorAna dos Santos
dc.creatorMaria Vidal
dc.creatorValentina Del Caro
dc.creatorRosinaldo Filho
dc.creatorHelem Dos Santos
dc.creatorRenato Santana de Aguiar
dc.creatorJosé Proença-Modena
dc.creatorBruce Nelson
dc.creatorJames Hay
dc.creatorMélodie Monod
dc.creatorDarlan da Candido
dc.creatorXenia Miscouridou
dc.creatorHelen Coupland
dc.creatorRaphael Sonabend
dc.creatorMichaela Vollmer
dc.creatorAxel Gandy
dc.creatorCarlos Prete
dc.creatorVitor Nascimento
dc.creatorMarc Suchard
dc.creatorThomas Bowden
dc.creatorSergei Pond
dc.creatorSwapnil Mishra
dc.creatorChieh-hsi Wu
dc.creatorOliver Ratmann
dc.creatorNeil Ferguson
dc.creatorChristopher Dye
dc.creatorNick Loman
dc.creatorPhilippe Lemey
dc.creatorAndrew Rambaut
dc.creatorNelson Fraiji
dc.creatorMaria do Carvalho
dc.creatorOliver Pybus
dc.creatorMyuki Crispim
dc.creatorSeth Flaxman
dc.creatorSamir Bhatt
dc.creatorEster Sabino
dc.creatorFlavia Sales
dc.creatorIwona Hawryluk
dc.date.accessioned2025-01-22T21:19:11Z
dc.date.accessioned2025-09-08T23:03:24Z
dc.date.available2025-01-22T21:19:11Z
dc.date.issued2021-04-14
dc.format.mimetypepdf
dc.identifier.doihttps:// doi:10.1126/science.abh2644
dc.identifier.issn0036-8075
dc.identifier.urihttps://hdl.handle.net/1843/79415
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScience
dc.rightsAcesso Aberto
dc.subjectCOVID-19 (Doença)
dc.subjectSARS-CoV-2
dc.subjectPandemia
dc.subjectMicrobiologia
dc.titleGenomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil
dc.typeArtigo de periódico
local.citation.epage821
local.citation.spage815
local.citation.volume372
local.description.resumoCases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil,resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampledin Manaus between November 2020 and January 2021 revealed the emergence and circulation of anovel SARS-CoV-2 variant of concern. Lineage P.1 acquired 17 mutations, including a trio in thespike protein (K417T, E484K, and N501Y) associated with increased binding to the human ACE2(angiotensin-converting enzyme 2) receptor. Molecular clock analysis shows that P.1 emergenceoccurred around mid-November 2020 and was preceded by a period of faster molecular evolution. Usinga two-category dynamical model that integrates genomic and mortality data, we estimate that P.1may be 1.7- to 2.4-fold more transmissible and that previous (non-P.1) infection provides 54 to 79% ofthe protection against infection with P.1 that it provides against non-P.1 lineages. Enhanced globalgenomic surveillance of variants of concern, which may exhibit increased transmissibility and/or immuneevasion, is critical to accelerate pandemic responsiveness.
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.science.org/doi/full/10.1126/science.abh2644?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Genomics and epidemiology of the P.1 SARS-CoV-2lineage in Manaus, Brazil.pdf
Tamanho:
8.58 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG