Systematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism

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dc.creatorParth Patel
dc.creatorPayal Patel
dc.creatorMeha Bhatt
dc.creatorCody Braun
dc.creatorHousne Begum
dc.creatorRobby Nieuwlaat
dc.creatorRasha Khatib
dc.creatorCarolina de Castro Martins
dc.creatorYuan Zhang
dc.creatorItziar Etxeandia-Ikobaltzeta
dc.creatorJamie Varghese
dc.creatorHani Alturkmani
dc.creatorWaled Bahaj
dc.creatorMariam Baig
dc.creatorRohan Kehar
dc.creatorAhmad Mustafa
dc.creatorRakesh Ponnapureddy
dc.creatorAnchal Sethi
dc.creatorMerrill Thomas
dc.creatorDavid Wooldridge
dc.creatorWendy Lim
dc.creatorShannon Bates
dc.creatorEddy Lang
dc.creatorGrégoire Le Gal
dc.creatorLinda Haramati
dc.creatorJeffrey Kline
dc.creatorMarc Righini
dc.creatorWojtek Wiercioch
dc.creatorHolger Schunemann
dc.creatorReem Mustafa
dc.date.accessioned2024-04-29T20:09:00Z
dc.date.accessioned2025-09-09T00:16:31Z
dc.date.available2024-04-29T20:09:00Z
dc.date.issued2021-04
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1182/bloodadvances.2020002398
dc.identifier.issn2473-9537
dc.identifier.urihttps://hdl.handle.net/1843/67888
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBlood Advances
dc.rightsAcesso Restrito
dc.subjectAnticoagulants
dc.subjectHemorrhage
dc.subjectPulmonary embolism
dc.subjectVenous thromboembolism
dc.subjectIntracranial hemorrhages
dc.subjectTomography, X-ray computed
dc.subjectTherapeutics
dc.subject.otherAnticoagulation
dc.subject.otherFibrin fragment d substance
dc.subject.otherFollow-up
dc.subject.otherHemorrhage
dc.subject.otherPulmonary embolism
dc.subject.otherVenous thromboembolism
dc.subject.otherIntracranial hemorrhages
dc.subject.otherComputed tomography
dc.subject.otherTherapeutic intervention
dc.subject.otherEmbase
dc.titleSystematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism
dc.typeArtigo de periódico
local.citation.epage2244
local.citation.issue8
local.citation.spage2237
local.citation.volume5
local.description.resumoPrompt evaluation and therapeutic intervention of suspected pulmonary embolism (PE) are of paramount importance for improvement in outcomes. We systematically reviewed outcomes in patients with suspected PE, including mortality, incidence of recurrent PE, major bleeding, intracranial hemorrhage, and postthrombotic sequelae. We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase for eligible studies, reference lists of relevant reviews, registered trials, and relevant conference proceedings. We included 22 studies with 15 865 patients. Among patients who were diagnosed with PE and discharged with anticoagulation, 3-month follow-up revealed that all-cause mortality was 5.69% (91/1599; 95% confidence interval [CI], 4.56-6.83), mortality from PE was 1.19% (19/1597; 95% CI, 0.66-1.72), recurrent venous thromboembolism (VTE) occurred in 1.38% (22/1597; 95% CI: 0.81-1.95), and major bleeding occurred in 0.90% (2/221%; 95% CI, 0-2.15). In patients with a low pretest probability (PTP) and negative D-dimer, 3-month follow-up revealed mortality from PE was 0% (0/808) and incidence of VTE was 0.37% (4/1094; 95% CI: 0.007-0.72). In patients with intermediate PTP and negative D-dimer, 3-month follow-up revealed that mortality from PE was 0% (0/2747) and incidence of VTE was 0.46% (14/3015; 95% CI: 0.22-0.71). In patients with high PTP and negative computed tomography (CT) scan, 3-month follow-up revealed mortality from PE was 0% (0/651) and incidence of VTE was 0.84% (11/1302; 95% CI: 0.35-1.34). We further summarize outcomes evaluated by various diagnostic tests and diagnostic pathways (ie, D-dimer followed by CT scan).
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://ashpublications.org/bloodadvances/article/5/8/2237/475796/Systematic-review-and-meta-analysis-of-outcomes-in

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