Intra-tumor genetic heterogeneity in wilms? tumor samples
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms’ tumors (WT). Children with
WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around
90% of overall survival in five years. WT is a genetically heterogeneous group with a low prevalence of known somatic alterations. Only
around 30% of the cases present mutation in known genes, and there is a relatively high degree of intra-tumor genetic heterogeneity
(ITGH). Besides potentially having an impact on the clinical outcome of patients, ITGH may interfere with the search for molecular
markers that are prospectively being tested by COG and SIOP. In this review, we present the proposal of the current UMBRELLA SIOP
Study 2017/Brazilian Renal Tumor Group that requires the multi-sampling collection of each tumor to better evaluate possible molecular
markers, as well as to understand WT biology
Abstract
Assunto
Wilms tumor, Biomarkers, Genetic Heterogeneity
Palavras-chave
Wilms tumor, Biomarkers, Genetic Heterogeneity
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https://doi.org/10.1590/1806-9282.65.12.1496