Alterações imunofuncionais hepáticas causadas por inóculo viral (MHV3), em animais portadores de NAFLD e NASH

Abstract

At the end of 2019, Covid-19 emerged from China and, in 2020, it was already considered a pandemic disease. Meanwhile, a silent pandemic became increasingly evident, affecting about one in four people, and becoming a constant in the medical records of infected individuals with the worst prognosis and highest hospital occupancy rates. NAFLD, previously seen as an inert condition, now reached greater relevance. With the objective of characterizing the spectra of this disease and verifying how it could alter the dynamics of the hepatic immune response, animals were submitted to dietary insults capable of inducing these conditions and then infected with a virus similar to the human coronavirus, the MHV3. It was verified that, regardless of the disease stage, animals that presented hepatic steatosis with subsequent infection, presented an increase in the hepatic necrotic area, as well as fibrosis in a more advanced stage and to a greater extent. Along with this, vascular changes, parenchymal dysmorphia, and changes in population dynamics with regard to resident cells and cell infiltrate were also noted. Therefore, in terms of public health, measures must be structured in order to alert the population to these possible risks, carrying out a prior diagnosis and encouraging habits that would mitigate the development of a more lethal condition of the disease, something avoidable, however, that ends up changing the dynamics of hospital care.