Polymorphic characterization and implications on biopharmaceutics properties of potential anti-inflammatory drug candidate eremantholide C from Lychnophora trichocarpha (Brazilian arnica)

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dc.creatorTamires Guedes Caldeira
dc.creatorDênia Antunes Saúde Guimarães
dc.creatorDâmaris Laignier Rodrigues de Lacerda
dc.creatorWagner da Nova Mussel
dc.creatorMaria Irene Yoshida
dc.creatorJacqueline de Souza
dc.date.accessioned2023-03-02T19:49:23Z
dc.date.accessioned2025-09-08T23:11:35Z
dc.date.available2023-03-02T19:49:23Z
dc.date.issued2019-06
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1111/jphp.13080
dc.identifier.issn2042-7158
dc.identifier.urihttps://hdl.handle.net/1843/50618
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Restrito
dc.subjectFísico-química
dc.subjectBiofarmacêutica
dc.subjectPolimorfismo (Cristalografia)
dc.subjectAgentes antiinflamatórios
dc.subjectArnica
dc.subjectSolubilidade
dc.subjectRaios X - Difração
dc.subjectEspectroscopia de infravermelho
dc.subjectCalorimetria
dc.subjectMicroscopia
dc.subject.otherDifferential scanning calorimetry
dc.subject.otherEremantholide C
dc.subject.otherIntrinsic dissolution
dc.subject.otherPolymorphism
dc.subject.otherSolubility
dc.subject.otherX-ray powder
dc.subject.otherDiffraction
dc.titlePolymorphic characterization and implications on biopharmaceutics properties of potential anti-inflammatory drug candidate eremantholide C from Lychnophora trichocarpha (Brazilian arnica)
dc.typeArtigo de periódico
local.citation.epage919
local.citation.issue6
local.citation.spage910
local.citation.volume71
local.description.resumoObjectives: To perform the polymorphic and physicochemical characterization of the potential anti-inflammatory drug, eremantholide C (EREC), as well as to evaluate the influence of these characteristics on its biopharmaceutics classification. Methods: Eremantholide C was obtained from chloroformic extract of Lychnophora trichocarpha and crystallized in two distinct solvents: chloroform (EREC 1) and ethyl acetate (EREC 2). To evaluate the polymorphism, EREC samples were submitted to melting point, purity, infrared spectroscopy, differential scanning calorimetry (DSC), X-ray powder diffraction, optical microscopy and scanning electron microscopy analysis. In addition, EREC samples crystallized after intrinsic dissolution study were submitted to DSC and X-ray powder diffraction analysis. Key findings: EREC 1 showed fusion at 234.7–241.6 °C, while EREC 2 showed fusion at 238.6–243.7 °C. No polymorphic transitions were observed during the intrinsic dissolution experiment. A single sharp endothermic peak was obtained for the EREC samples. X-ray diffraction showed no crystallographic differences between the EREC samples. EREC 1 and EREC 2 showed birefringence under polarized light and indefinite morphology; however, the shape of the crystals was common to the two samples. Conclusions: Eremantholide C does not present classical or morphological polymorphism; therefore, there is no influence of crystalline transitions in the solubility and consequently in its biopharmaceutics classification and oral absorption process.
local.identifier.orcidhttps://orcid.org/0000-0003-4028-0134
local.identifier.orcidhttps://orcid.org/0000-0002-7533-1248
local.identifier.orcidhttps://orcid.org/0000-0002-9768-9830
local.identifier.orcidhttps://orcid.org/0000-0002-6795-9457
local.identifier.orcidhttps://orcid.org/0000-0003-0869-023X
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/jpp/article/71/6/910/6122148

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