Treatment with Bifidobacterium longum 5 1A attenuates intestinal damage and inflammatory response in experimental colitis

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dc.creatorFernanda Alves Abrantes
dc.creatorBruna Bernardo Nascimento
dc.creatorMaria Emília Rabelo Andrade
dc.creatorPatrícia Aparecida Vieira de Barros
dc.creatorChristiane Teixeira Cartelle
dc.creatorFlaviano dos Santos Martins
dc.creatorJacques Robert Nicoli
dc.creatorRosa Maria Esteves Arantes
dc.creatorSimone de Vasconcelos Generoso
dc.creatorSimone Odília Antunes Fernandes
dc.creatorValbert Nascimento Cardoso
dc.date.accessioned2022-05-18T21:48:45Z
dc.date.accessioned2025-09-09T00:00:08Z
dc.date.available2022-05-18T21:48:45Z
dc.date.issued2019-02
dc.identifier.doi10.3920/bm2019.0098
dc.identifier.issn1876-2883
dc.identifier.urihttps://hdl.handle.net/1843/41807
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBeneficial Microbes
dc.rightsAcesso Restrito
dc.subjectDoenças inflamatórias intestinais
dc.subjectBifidobacterium
dc.subjectColite
dc.subject.otherBifidobacterium longum 51A
dc.subject.otherColitis
dc.subject.otherIntestinal epithelium
dc.subject.otherInflammatory bowel diseases
dc.subject.otherProbiotic
dc.titleTreatment with Bifidobacterium longum 5 1A attenuates intestinal damage and inflammatory response in experimental colitis
dc.typeArtigo de periódico
local.citation.epage57
local.citation.issue1
local.citation.spage47
local.citation.volume11
local.description.resumoThis study evaluated the effects of Bifidobacterium longum 51A on the intestinal mucosa and inflammatory response in experimental colitis. Colitis was induced by administration of 3.5% dextran sodium sulphate (DSS) solution for 7 days. Two periods of administration were performed: treatment (T) group, mice received Bifidobacterium only during disease induction (7 days); total treatment (TT) group, mice received Bifidobacterium for 10 days before and during disease induction. The probiotic effects on intestinal permeability, inflammatory infiltrate, histological analysis, cytokines, chemokines and sIgA were evaluated. Bifidobacterium administration in the T group showed reduction in intestinal permeability and lower IL-1β, myeloperoxidase, and eosinophil peroxidase levels compared to those in the colitis group (P<0.05). Bifidobacterium administration in the TT group attenuated severe lesions in the colon and reduced eosinophil peroxidase level (P<0.05). B. longum 51A treatment modality was more effective than total treatment and reduced the inflammatory response and its consequences on intestinal epithelium.
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.wageningenacademic.com/doi/10.3920/BM2019.0098

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