Repurposing approved drugs for guiding COVID-19 Prophylaxis: a systematic review

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dc.creatorBruno Silva Andrade
dc.creatorFernanda de Souza Rangel
dc.creatorNaiane Oliveira Santos
dc.creatorAndria Dos Santos Freitas
dc.creatorWagner Rodrigues de Assis Soares
dc.creatorSergio Siqueira
dc.creatorDebmalya Barh
dc.creatorAristóteles Góes Neto
dc.creatorAlexander Birbrair
dc.creatorVasco Ariston de Carvalho Azevedo
dc.date.accessioned2023-06-21T20:05:00Z
dc.date.accessioned2025-09-08T23:55:31Z
dc.date.available2023-06-21T20:05:00Z
dc.date.issued2020
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fphar.2020.590598
dc.identifier.issn1663-9812
dc.identifier.urihttps://hdl.handle.net/1843/55213
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Pharmacology
dc.rightsAcesso Aberto
dc.subjectSARS-CoV-2
dc.subjectAntivirais
dc.subjectReposicionamento de Medicamentos
dc.subjectCOVID-19
dc.subject.otherSARS-CoV-2
dc.subject.otherProphylaxis
dc.subject.otherAntiviral
dc.subject.otherDrug repurposing
dc.subject.otherCOVID-19
dc.titleRepurposing approved drugs for guiding COVID-19 Prophylaxis: a systematic review
dc.title.alternativeReaproveitamento de medicamentos aprovados para orientar a profilaxia da COVID-19: uma revisão sistemática
dc.typeArtigo de periódico
local.citation.volume11
local.description.resumoThe SARS-CoV-2 outbreak originally appeared in China in December 2019 and became a global pandemic in March 2020. This infectious disease has directly affected public health and the world economy. Several palliative therapeutic treatments and prophylaxis strategies have been used to control the progress of this viral infection, including pre-(PrEP) and post-exposure prophylaxis. On the other hand, research groups around the world are still studying novel drug prophylaxis and treatment using repurposing approaches, as well as vaccination options, which are in different pre-clinical and clinical testing phases. This systematic review evaluated 1,228 articles from the PubMed and Scopus indexing databases, following the Kitchenham bibliographic searching protocol, with the aim to list drug candidates, potentially approved to be used as new options for SARS-CoV-2 prophylaxis clinical trials and medical protocols. In searching protocol, we used the following keywords: “Covid-19 or SARS-CoV-2” or “Coronavirus or 2019 nCoV,” “prophylaxis,” “prophylactic,” “pre-exposure,” “COVID-19 or SARS-CoV-2 Chemoprophylaxis,” “repurposed,” “strategies,” “clinical,” “trials,” “anti-SARS-CoV-2,” “anti-covid-19,” “Antiviral,” “Therapy prevention in vitro,” in cells “and” human testing. After all protocol steps, we selected 60 articles that included: 15 studies with clinical data, 22 studies that used in vitro experiments, seven studies using animal models, and 18 studies performed with in silico experiments. Additionally, we included more 22 compounds between FDA approved drugs and drug-like like molecules, which were tested in large-scale screenings, as well as those repurposed approved drugs with new mechanism of actions. The drugs selected in this review can assist clinical studies and medical guidelines on the rational repurposing of known antiviral drugs for COVID-19 prophylaxis.
local.identifier.orcidhttps://orcid.org/0000-0002-8031-9454
local.identifier.orcidhttps://orcid.org/0000-0001-5138-9042
local.identifier.orcidhttps://orcid.org/0000-0001-9041-9777
local.identifier.orcidhttps://orcid.org/0000-0001-9254-6550
local.identifier.orcidhttps://orcid.org/0000-0002-2557-7768
local.identifier.orcidhttps://orcid.org/0000-0002-7692-6243
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fphar.2020.590598/full

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