A comparison of single versus multipletablet regimens in HIV-infected people initiating antiretroviral therapy

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dc.creatorCelline Cardoso Almeida Brasil
dc.creatorJuliana Oliveira Costa
dc.creatorElizabeth Nascimento
dc.creatorRomara Elizeu Amaro Perdigão
dc.creatorMicheline Rosa Silveira
dc.creatorPalmira de Fátima Bonolo
dc.creatorFrancisco de Assis Acurcio
dc.creatorMaria Das Graças Braga Ceccato
dc.date.accessioned2022-10-18T22:14:18Z
dc.date.accessioned2025-09-09T01:02:00Z
dc.date.available2022-10-18T22:14:18Z
dc.date.issued2017-08-22
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1002/pds.4275
dc.identifier.issn1099-1557
dc.identifier.urihttps://hdl.handle.net/1843/46343
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Conference on Pharmacoepidemiology & Therapeutic Risk Management
dc.rightsAcesso Aberto
dc.subjectHIV
dc.subjectTerapia antirretroviral
dc.subjectMedicamentos
dc.subject.otherHIV
dc.subject.otherTerapia antirretroviral
dc.subject.otherMedicamentos
dc.titleA comparison of single versus multipletablet regimens in HIV-infected people initiating antiretroviral therapy
dc.typeArtigo de evento
local.citation.epage343
local.citation.issue33rd International Conference on Pharmacoepidemiology & Therapeutic Risk Management
local.citation.spage343
local.description.resumoBackground: The once-daily single-tablet regimen (STR) containing efavirenz, tenofovir and lamivudine is the first choice for HIV-infected people initiating antiretroviral therapy (ART) in Brazil and few studies have examined its influence on treatment and healthrelated characteristics compared to multiple-tablet regimen (MTR). Objectives: To evaluate the differences of antiretroviral therapy as a STR and MTR regarding treatment and health-related characteristics. Methods: Baseline evaluation of a cohort of 184 HIVinfected adults (79% male, mean age 35.9) with six or less months of ART under care in a reference hospital in Belo Horizonte, Brazil. Recruitment occurred between Sep/2015 and Aug/2016, and data were obtained through face-to-face interviews. Quality of life (QoL), symptoms of anxiety and depression, health state and adherence were assessed through self-report using validated instruments. A 40-item instrument to be validated during the cohort was used to assess perceived barriers with ART. The regimen used was collected from the Brazilian ART delivery database system (SICLOM). STR and MTR users were compared through non-parametric tests using Stata v.14. Results: A slightly lower proportion of STR versus MTR patients were non-adherent (54% vs 57%) and had adverse effects (85% vs. 88%), anxiety symptoms (36% vs. 41%) and depression symptoms (27% vs. 31%), though the statistical difference was not significant (p > 0.05). The STR group showed a higher QoL in the independence domain (p<0.01) (WHOQoLHIV-bref) and a better self-perception of health (p<0.05) (EQ5D VAS) than MTR group. The MTR group had twice the odds of having difficulties with the treatment (p<0.05). The perceived barriers associated with MTR were “incorporate ART into work routine” (p<0.05), “swallow the pills” (p= 0.05) and “social isolation (p<0.01)”. Conclusions: All the characteristics analyzed in this study tended to be better for patients using STR. Although adherence was not significantly higher in STR group, patients reporting difficulties with treatment had twice the odds of being non-adherent. The results indicate that single-tablet regimens may help patients in the management of ART, reflecting in aspects of daily life activities and self-perception of health.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE FARMÁCIA SOCIAL
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1002/pds.4275

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