Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice

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dc.creatorAngélica Thomaz Vieira
dc.creatorIzabela Galvão
dc.creatorLaurence M. Macia
dc.creatorÉrica Moraes Sernaglia
dc.creatorMarco Aurélio Ramirez Vinolo
dc.creatorCristiana Couto Garcia
dc.creatorLuciana Pádua Tavares
dc.creatorFlávio Almeida Amaral
dc.creatorLirlândia Pires de Sousa
dc.creatorFlaviano dos Santos Martins
dc.creatorCharles Reay Mackay
dc.creatorMauro Martins Teixeira
dc.date.accessioned2022-03-01T20:01:42Z
dc.date.accessioned2025-09-09T01:09:53Z
dc.date.available2022-03-01T20:01:42Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1189/jlb.3A1015-453RRR
dc.identifier.issn1938-3673
dc.identifier.urihttps://hdl.handle.net/1843/39765
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Leukocyte Biology
dc.rightsAcesso Aberto
dc.subjectFibras na dieta
dc.subjectGota
dc.subjectInflamação
dc.titleDietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice
dc.typeArtigo de periódico
local.citation.epage284
local.citation.issue1
local.citation.spage275
local.citation.volume101
local.description.resumoGout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the joints. Continuous gout episodes may lead to unresolved inflammatory responses and tissue damage. We investigated the effects of a high-fiber diet and acetate, a short-chain fatty acid (SCFA) resulting from the metabolism of fiber by gut microbiota, on the inflammatory response in an experimental model of gout in mice. Injection of MSU crystals into the knee joint of mice induced neutrophil influx and inflammatory hypernociception. The onset of inflammatory response induced by MSU crystals was not altered in animals given a high-fiber diet, but the high-fiber diet induced faster resolution of the inflammatory response. Similar results were obtained in animals given the SCFA acetate. Acetate was effective, even when given after injection of MSU crystals at the peak of the inflammatory response and induced caspase-dependent apoptosis of neutrophils that accounted for the resolution of inflammation. Resolution of neutrophilic inflammation was associated with decreased NF-κB activity and enhanced production of anti-inflammatory mediators, including IL-10, TGF-β, and annexin A1. Acetate treatment or intake of a high-fiber diet enhanced efferocytosis, an effect also observed in vitro with neutrophils treated with acetate. In conclusion, a high-fiber diet or one of its metabolic products, acetate, controls the inflammatory response to MSU crystals by favoring the resolution of the inflammatory response. Our studies suggest that what we eat plays a determinant role in our capacity to fine tune the inflammatory response.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.initialsUFMG

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