Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil

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dc.creatorTauyne Menegaldo Pinheiro
dc.creatorBárbara Aparecida Chaves
dc.creatorMayara Marques Carneiro da Silva
dc.creatorIzabella Cristina Andrade Batista
dc.creatorMichelle Premazzi Papa
dc.creatorLana Monteiro Meuren
dc.creatorCarolina Gonçalves de Oliveira Lucas
dc.creatorFlavio Lemos Matassoli
dc.creatorLaura Helena Vega Gonzales Gil
dc.creatorAdriana Bozzi
dc.creatorCarlos Eduardo Calzavara Silva
dc.creatorMânlio Tasso de Oliveira Mota
dc.creatorLuciana Barros de Arruda
dc.creatorDanielle da Glória de Souza
dc.creatorMauro Martins Teixeira
dc.creatorNikos Vasilakis
dc.creatorMaurício Lacerda Nogueira
dc.creatorAripuanã Sakurada Aranha Watanabe
dc.creatorJoice Matos Biselli Périco
dc.creatorBetânia Paiva Drumond
dc.creatorMilene Rocha Ribeiro
dc.creatorDanila Vedovello
dc.creatorJoão Pessoa Araújo
dc.creatorPaulo Filemon Paolucci Pimenta
dc.date.accessioned2023-07-14T20:36:33Z
dc.date.accessioned2025-09-08T23:34:34Z
dc.date.available2023-07-14T20:36:33Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0006525
dc.identifier.issn1935-2735
dc.identifier.urihttps://hdl.handle.net/1843/56301
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPLOS Neglected Tropical Diseases
dc.rightsAcesso Aberto
dc.subjectDengue - Epidemiologia
dc.subjectSão Jose do Rio Preto, Região de (SP)
dc.subject.otherDengue virus (DENV)
dc.subject.otherSão José do Rio Preto, Brazil
dc.subject.otherGenotype V
dc.subject.otherEpidemics
dc.titleViral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil
dc.typeArtigo de periódico
local.citation.epage25
local.citation.issue5
local.citation.spage1
local.citation.volume12
local.description.resumoThe dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in São José do Rio Preto.
local.identifier.orcidhttps://orcid.org/0000-0002-0828-9879
local.identifier.orcidhttps://orcid.org/0000-0003-1957-666X
local.identifier.orcidhttps://orcid.org/0000-0001-8198-6016
local.identifier.orcidhttps://orcid.org/0000-0002-8242-5584
local.identifier.orcidhttps://orcid.org/0000-0002-1406-6401
local.identifier.orcidhttps://orcid.org/0000-0003-3432-0769
local.identifier.orcidhttps://orcid.org/0000-0002-6944-3008
local.identifier.orcidhttps://orcid.org/0000-0003-1102-2419
local.identifier.orcidhttps://orcid.org/0000-0003-0875-2269
local.identifier.orcidhttps://orcid.org/0000-0001-5105-9537
local.identifier.orcidhttps://orcid.org/0000-0002-4177-7532
local.identifier.orcidhttps://orcid.org/0000-0001-8585-8206
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006525

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