FML/QuilA-vaccinated dogs naturally infected with Leishmania infantum: serum cytokines, clinicopathological profile, and parasitological parameters

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dc.creatorGregório Guilherme Almeida
dc.creatorFernanda Morcatti Coura
dc.creatorJonata de Melo Barbieri
dc.creatorAna Carolina Junqueira Moura
dc.creatorFabiola de Oliveira Paes Leme
dc.creatorAdriane Pimenta da Costa-Val
dc.date.accessioned2024-04-18T20:40:46Z
dc.date.accessioned2025-09-09T01:09:53Z
dc.date.available2024-04-18T20:40:46Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.identifier.doihttps://doi.org/10.1155/2021/3192960
dc.identifier.issn2314-6141
dc.identifier.urihttps://hdl.handle.net/1843/67437
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBioMed Research International
dc.rightsAcesso Aberto
dc.subjectLeishmania infantum
dc.subjectVacinas
dc.subjectCitocinas
dc.subjectCães
dc.subject.otherLeishmania infantum
dc.subject.otherVaccines
dc.subject.otherCytokines
dc.subject.otherVaccinated dogs
dc.titleFML/QuilA-vaccinated dogs naturally infected with Leishmania infantum: serum cytokines, clinicopathological profile, and parasitological parameters
dc.typeArtigo de periódico
local.citation.volume2021
local.description.resumoDogs are the main reservoir of Leishmania infantum in endemic regions. Canine leishmaniasis, caused by L. infantum, can progress to a chronic disease resulting in death. Vaccines have been developed with a certain degree of success. The pathogenesis of this disease is not completely understood, especially in previously vaccinated dogs. We herein described clinical data, parasite load, serum levels of cytokines, and the reservoir potential in vdogs vaccinated with the fucose-mannose ligand (FML)/QuilA saponin vaccine (Leishmune™) naturally infected (Vi) and compared to vaccinated not infected dogs (Vn). Thirty-four dogs from private owners were divided into two groups: vaccinated/infected and vaccinated/uninfected. Clinical evaluation, hematological and biochemical parameters, and serum levels of cytokines were measured by conventional methods. The parasite burden in the bone marrow was measured by quantitative real-time PCR, and the transmissibility of parasites to sand flies was assessed by xenodiagnosis. Clinical, biochemical, and hematological parameters of vaccinated infected dogs were mostly normal. Vi dogs developed mild disease with low clinical scores. Serum levels of IL-10 were higher in Vi dogs, and a strong correlation was observed in IL-4 levels and the A/G ratio in Vi dogs. These results suggest a role of TH2 response in Vi dogs, although more data is needed to better understand the disease in vaccinated dogs.
local.identifier.orcidhttps://orcid.org/0000-0003-1108-1160
local.identifier.orcidhttps://orcid.org/0000-0003-2243-3125
local.identifier.orcidhttps://orcid.org/0000-0003-1044-3473
local.identifier.orcidhttps://orcid.org/0000-0001-7555-1956
local.identifier.orcidhttps://orcid.org/0000-0002-4013-0147
local.identifier.orcidhttps://orcid.org/0000-0001-8995-9805
local.publisher.countryBrasil
local.publisher.departmentVET - DEPARTAMENTO DE CLÍNICA E CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://www.hindawi.com/journals/bmri/2021/3192960/

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