Clinicopathological analysis of oral and maxillofacial Acinic cell carcinoma: a systematic review

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dc.creatorLaura Borges Kirschnick
dc.creatorVivian Petersen Wagner
dc.creatorFelipe Paiva Fonseca
dc.creatorManoela Domingues Martins
dc.creatorFelipe Martins Silveira
dc.creatorLauren Frenzel Schuch
dc.creatorMarco Antonio Martins
dc.creatorMárcio Ajudarte Lopes
dc.creatorAlan Roger dos Santos-Silva
dc.creatorVinicius Coelho Carrard
dc.creatorJean Nunes dos Santos
dc.creatorPablo Agustin Vargas
dc.date.accessioned2024-03-06T19:18:48Z
dc.date.accessioned2025-09-08T23:47:21Z
dc.date.available2024-03-06T19:18:48Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.1111/jop.13159
dc.identifier.issn09042512
dc.identifier.urihttps://hdl.handle.net/1843/65379
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of oral pathology & medicine
dc.rightsAcesso Restrito
dc.subjectCarcinoma, Acinar cell
dc.subjectMouth neoplasms
dc.subjectPrognosis
dc.subjectParotid gland
dc.subjectRecurrence
dc.subjectNeoplasm metastasis
dc.subject.otherNeoplasia de glândula salivar
dc.subject.other11acesso restrito assunto: Mouth NeoplasmsClinicopathological analysis of oral and maxillofacial acinic cell carcinoma: a systematic review nome periódico Journal of oral pathology & medicine busca dia 11/12/2023 fao clínica assunto
dc.titleClinicopathological analysis of oral and maxillofacial Acinic cell carcinoma: a systematic review
dc.typeArtigo de periódico
local.citation.epage749
local.citation.issues
local.citation.spage741
local.citation.volume50
local.description.resumoBackground: The aim of the present systematic review was to analyze the available data regarding acinic cell carcinoma of the oral and maxillofacial region. Methods: A search strategy was performed using PubMed, Web of Science, Scopus, and Embase electronic databases. Results: Available data revealed a slight female preference (54.73%) and a mean age at diagnosis of 47.51 ± 19.85 years. The parotid glands (67.72%) were most frequently affected, and most cases were asymptomatic (69.54%). A microcystic histopathological pattern was reported in 21.56% of the cases, and the Periodic acid-Schiff was the staining method most frequently used, after the hematoxylin and eosin staining, in the tumors analyzed. The lesions were mainly treated by surgical removal (72.32%). Recurrence was reported in 81 cases (27.83%) and metastasis in 100 (42.91%). Statistical data analysis revealed that tumors located in major salivary glands and exhibiting high-grade histology were associated with local recurrence (P = .01). In addition, the patients older than 57 years, lesions with bone involvement, the high-grade tumors and the cases with a history of recurrence and metastasis were associated with a lower overall survival (P < .05). Conclusion: By assembling all eligible cases in the literature, the present systematic review determined the most common clinicopathological profile of acinic cell carcinoma and the most relevant prognostic factors in a distinctly representative sample. The survey demonstrated the importance of considering the histopathological grading in order to better define the treatment for each case.
local.identifier.orcids
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13159

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