Epigenetic alterations in ameloblastomas: a literature review
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Data
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Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
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Membros da banca
Resumo
Background
Ameloblastoma is a locally aggressive tumor, originated from odontogenic epithelium, and affects the jawbones with an elevated recurrence rate. The molecular mechanisms involved with the pathogenesis of this tumor remain undetermined. This review aimed to describe the current data regarding epigenetic alterations in ameloblastoma.
Material and Methods
A systematized electronic search was performed in the English-language literature in three databases, combining the following keywords: ameloblastoma, epigenetic, methylation, noncoding RNA, histone acetylation.
Results
According to the gathered results of 11 studies in this review, epigenetic alterations could induce the development and progression of ameloblastoma. DNA methylation has been the most assessed mechanism in ameloblastomas.
Conclusions
Current literature data indicate that epigenetic events can be involved in the etiopathogenesis of ameloblastomas.
Abstract
Assunto
Ameloblastoma, Epigenomics, Methylation, RNA, untranslated, Enzymes, Acetylation
Palavras-chave
Tumores odontogênicos, título periódico: busca dia 27/11/2023 d.c depois de Cristo título periódico Journal of clinical and experimental dentistry assunto ameloblastoma fao clínica
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Curso
Endereço externo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920560/