Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer

Página do item simplificado
dc.creatorMoacyr Ferreira Júnior
dc.creatorSérgio de Assis Batista
dc.creatorRafael Calvão Barbuto
dc.creatorAdriana d Gomes
dc.creatorDulciene Maria de Magalhães Queiroz
dc.creatorIvana Duval Araújo
dc.creatorMarcelo Vidigal Caliari
dc.date.accessioned2023-06-02T21:08:52Z
dc.date.accessioned2025-09-08T23:05:14Z
dc.date.available2023-06-02T21:08:52Z
dc.date.issued2017
dc.format.mimetypepdf
dc.identifier.urihttps://hdl.handle.net/1843/54420
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBMC Microbiology
dc.rightsAcesso Aberto
dc.subjectHelicobacter pylori
dc.subjectNeoplasias Gástricas
dc.subjectÚlcera Péptica
dc.subjectBrasil
dc.subject.otherHelicobacter pylori
dc.subject.otherGastric cancer
dc.subject.otherPeptic ulcera
dc.subject.otherBrazil
dc.titleHigher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer
dc.typeArtigo de periódico
local.citation.epage7
local.citation.issue61
local.citation.spage1
local.citation.volume11
local.description.resumoBackground: Helicobacter pylori infection is one of the most common infections worldwide and is associated with gastric cancer and peptic ulcer. Bacterial virulence factors such as CagA have been shown to increase the risk of both diseases. Studies have suggested a causal role for CagA EPIYA polymorphisms in gastric carcinogenesis, and it has been shown to be geographically diverse. We studied associations between H. pylori CagA EPIYA patterns and gastric cancer and duodenal ulcer, in an ethnically admixed Western population from Brazil. CagA EPIYA was determined by PCR and confirmed by sequencing. A total of 436 patients were included, being 188 with gastric cancer, 112 with duodenal ulcer and 136 with gastritis. Results: The number of EPIYA C segments was significantly associated with the increased risk of gastric carcinoma (OR = 3.08, 95% CI = 1.74 to 5.45, p < 10-3) even after adjustment for age and gender. Higher number of EPIYA C segments was also associated with gastric atrophy (p = 0.04) and intestinal metaplasia (p = 0.007). Furthermore,patients infected by cagA strains possessing more than one EPIYA C segment showed decreased serum levels of pepsinogen I in comparison with those infected by strains containing one or less EPIYA C repeat. Otherwise, the number of EPIYA C segments did not associate with duodenal ulcer. Conclusions: Our results demonstrate that infection with H. pylori strains harbouring more than one CagA EPIYA C motif was clearly associated with gastric cancer, but not with duodenal ulcer. Higher number of EPIYA C segments was also associated with gastric precancerous lesions as demonstrated by histological gastric atrophic and metaplastic changes and decreased serum levels of pepsinogen I.
local.identifier.orcidhttps://orcid.org/0000-0001-6488-734X
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-11-61

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer
Tamanho:
161.2 KB
Formato:
Unknown data format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG