Caryocar brasiliense Camb. fruit peel butanolic fraction induces antiproliferative effects against murine melanoma cell line

Página do item simplificado
dc.creatorJéssica Nayara Basílio Silva
dc.creatorVictor Hugo Dantas Guimarães
dc.creatorBarbhara Mota Marinho
dc.creatorAmanda Souto Machado
dc.creatorAmanda Rodrigues Santos
dc.creatorLudmilla Regina de Souza David
dc.creatorGeraldo Aclécio Melo
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorSergio Henrique Sousa Santos
dc.date.accessioned2023-11-10T20:45:59Z
dc.date.accessioned2025-09-09T00:03:20Z
dc.date.available2023-11-10T20:45:59Z
dc.date.issued2022
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.phyplu.2022.100273
dc.identifier.issn2667-0313
dc.identifier.urihttps://hdl.handle.net/1843/60811
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPhytomedicine Plus
dc.rightsAcesso Aberto
dc.subjectPlantas medicinais
dc.subjectCromatografia a gás
dc.subjectMelanoma
dc.subjectFenologia vegetal
dc.subject.otherMedicinal plant
dc.subject.otherCutaneous malignant melanoma
dc.subject.otherPhenolic compounds
dc.subject.otherFolk medicine cells
dc.subject.otherChromatography
dc.titleCaryocar brasiliense Camb. fruit peel butanolic fraction induces antiproliferative effects against murine melanoma cell line
dc.typeArtigo de periódico
local.citation.epage9
local.citation.issue2
local.citation.spage100273
local.citation.volume2
local.description.resumoBackground: Cutaneous malignant melanoma is a skin cancer type highly resistant to standard cancer therapies. Natural compounds have been reported as important sources for the creation of new drugs for cancer treatment. Caryocar brasiliense Camb., popularly known as Pequi, is often used in Brazilian folk medicine, with anticancer effects reported. Objectives: The present study evaluated the antiproliferative activity of the crude extract butanolic fraction of the C. brasiliense Camb. peel on the B16F10 cell linage Method: C. brasiliense peel fraction was analyzed by Gas Chromatography coupled to massa spectra, and its biological effects were evaluated on the melanoma cell line B16F10. Results: The chromatography analysis of the butanolic fraction of the C. brasiliense peel fraction identified a majority presence of gallic acid and sarothrin compounds. These compounds might have been responsible for an antiproliferative effect on B16F10, with the inhibitory concentration (IC50) equal to 390.9 µg/mL (24 h) and 226.4 µg/mL (48 h) after treatments. Our results revealed that cell death assay via bromide and acridine orange tests indicated an increase in cell death observed after 24 h treatment with the pequi fraction at 250 μg/mL (p < 0.05) and 500 μg/mL (p < 0.01). In addition, a significant increase in cell death at 250 μg/mL (p < 0.01) and 500 μg/mL (p < 0.0001) occurred after 48 h. Furthermore, a significant reduction in migratory activity in cells treated at 250 μg/mL (p < 0.05) and 500 μg/mL (p < 0.01) occurred and was enhanced by the 48 h treatment (p < 0.001).
local.publisher.countryBrasil
local.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA PRODUÇÃO
local.publisher.departmentMEDICINA - FACULDADE DE MEDICINA
local.publisher.departmentVET - DEPARTAMENTO DE TECNOLOGIA E INSPEÇÃO DE PRODUTOS DE ORIGEM ANIMAL
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2667031322000574?via%3Dihub

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Caryocar brasiliense Camb. fruit peel butanolic fraction induces antiproliferative effects against murine melanoma cell line.pdf
Tamanho:
1.24 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
978 B
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG