Total cholesterol and low-density lipoprotein alterations in children and adolescents from Brazil: a prevalence meta-analysis

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dc.creatorThales Philipe Rodrigues da Silva
dc.creatorLarissa Loures Mendes
dc.creatorVirgínia Maria Jorge Barreto
dc.creatorFernanda Penido Matozinhos
dc.creatorCamila Kümmel Duarte
dc.date.accessioned2024-04-05T20:17:57Z
dc.date.accessioned2025-09-09T00:17:54Z
dc.date.available2024-04-05T20:17:57Z
dc.date.issued2023-02
dc.format.mimetypepdf
dc.identifier.doi10.20945/2359-3997000000508
dc.identifier.issn2359-3997
dc.identifier.urihttps://hdl.handle.net/1843/66900
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Endocrinology Metabolism
dc.rightsAcesso Aberto
dc.subjectDislipidemias
dc.subjectCriança
dc.subjectAdolescente
dc.subjectColesterol
dc.subjectLipoproteínas LDL
dc.titleTotal cholesterol and low-density lipoprotein alterations in children and adolescents from Brazil: a prevalence meta-analysis
dc.typeArtigo de periódico
local.citation.epage44
local.citation.issue1
local.citation.spage19
local.citation.volume67
local.description.resumoObjective: The aim of the present study was to evaluate the prevalence of total cholesterol (TC) and low-density lipoprotein (LDL) alterations in children and adolescents in Brazil. Materials and methods: A systematic review and meta-analysis of prevalence. The search for articles was carried out in the databases: Medline (PubMed), Embase, Scientific Electronic Library Online (SciELO), Latin American and Caribbean Literature in Health Sciences (Lilacs). The meta-analysis was performed using the random effects model. The I² test was used to identify heterogeneity. Results: The present metanalysis revealed a significant prevalence of altered lipid profile in children and adolescents in Brazil. Regarding lipoprotein fractions, the prevalence of altered TC level was 27.47% (95% CI 24.36- 30.82), and a smaller prevalence was observed for LDL cholesterol (19.29% – 95% CI 15.21-24.16). The models revealed high heterogeneity (I² = 99%; p < 0.01), however the precise source of it was not identified; although type of school, age group, year and the region of Brazil appeared to influence the estimations of altered lipid profiles. Conclusion: An important prevalence of lipid alterations was observed among Brazilian children and adolescents. Those results reinforce the importance of knowing the lipid profile of children and adolescents to perform early interventions for this public.
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/aem/a/W9MFsX9R5DSZf3xNRgbZk6b/?lang=en#

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