Tratamento do carcinoma odontogênico de células clarasrevisão sistemática

Abstract

The Clear Cell Odontogenic is a rare jaw neoplasm and displays aggressive grow pattern and metastatic potential. Preferentially occurs in the mandible and shows female predilection. The aim of this study was to conduct a systematic review of clinical casespublished in the literature and compare the treatments outcome. The search of references was performed in the following databases: PubMed (www.pubmed.gov), The Cochrane Library (www.cochrane.org / index.htm), The Web of Science (www.isiknowledge). Fortyseven reports were included in this review and 67 clinical cases were analyzed. Six cases were treated by curettage, six by enucleation and 53 cases by resective surgery , with or without radiation therapy or neck dissection surgery. One case was treated by palliative chemotherapy and immunotherapy. One patient refused surgical treatment . Recurrencesoccurred in 45% of cases and 19.4 % of patients developed metastases. The recurrence rate was 92 % for those treated by curettage or enucleation and 34 % for cases of resective surgery. Seventy percent of patients had no evidence of disease after the last intervention.Eight patients (12 %) died from the disease. The treatment of choice is resective surgery with a tumor-free margins. Adjuvant radiation therapy should be considered in cases that adjacent soft tissues are involved or when is not possible achieve clear margins. Long-term follow-up is recommended .