HIF-1 α is associated with resistance to hypoxia-induced apoptosis in ameloblastoma

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dc.creatorKatherine Julissa Palma Valladares
dc.creatorSérgio de Melo Alves Júnior
dc.creatorJoão de Jesus Viana Pinheiro
dc.creatorKarolyny Martins Balbinot
dc.creatorAntonia Taiane Lopes de Moraes
dc.creatorMaria Sueli da Silva Kataoka
dc.creatorAline Maria Pereira Cruz Ramos
dc.creatorRommel Thiago Jucá Ramos
dc.creatorArtur Luiz da Costa da Silva
dc.creatorRicardo Alves de Mesquita
dc.creatorDavid Normando
dc.date.accessioned2024-11-01T12:03:55Z
dc.date.accessioned2025-09-09T00:55:08Z
dc.date.available2024-11-01T12:03:55Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1155/2021/3060375
dc.identifier.issn1687-8736
dc.identifier.urihttps://hdl.handle.net/1843/77769
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Dentistry
dc.rightsAcesso Aberto
dc.subjectCorrelation of data
dc.subjectAssociation
dc.subjectSignal transduction
dc.subjectHypoxia
dc.subjectProteins
dc.subjectApoptosis regulatory proteins
dc.titleHIF-1 α is associated with resistance to hypoxia-induced apoptosis in ameloblastoma
dc.typeArtigo de periódico
local.citation.epage10
local.citation.issue27
local.citation.spage1
local.citation.volume2021
local.description.resumoBackground: Ameloblastoma (AMB) is a benign odontogenic tumour, with an aggressive local behaviour and a high rate of recurrence. Previous studies have demonstrated that hypoxia-induced factor alpha 1 (HIF-1α) and activated caspase-3 contribute to tumour invasiveness and cytogenesis in ameloblastoma. Hypoxia increases HIF-1α levels, which triggers a number of signalling pathways. This paper aimed to present data in the study of hypoxia-activated signalling pathways that modulate proapoptotic and antiapoptotic events in AMB. Methods: Twenty cases of AMB and ten cases of dental follicle (DF) were used to analyse the immunoexpression of HIF-1α, p53, BNIP3, Bcl-2, IAP-2, GLUT1, and Bax. To contribute to the study, an analysis of expression and genetic interaction was performed using the cell line AME-1. Results: AMB and DF expressed the studied proteins. These proteins showed significantly greater immunoexpression in AMB compared with the DF (p < 0.05). HIF-1α showed an important association with GLUT1, and a positive correlation was observed among p53, Bcl-2, and IAP-2. Transcriptomic analysis showed the significant expression of the studied proteins, and the network generated showed a direct association of HIF-1αF with GLUT1 (SLC2A1), TP53, and LDHA. Interestingly, GLUT1 also exhibited direct interaction with TP53 and LDHA. Conclusion: In AMB tumorigenesis, hypoxia is possibly related to antiapoptotic events, which suggests an important role for HIF-1α, GLUT1, Bcl-2, IAP-2, and possibly p53.
local.identifier.orcidhttps://orcid.org/0000-0003-4721-8165
local.identifier.orcidhttps://orcid.org/0000-0003-0272-9279
local.identifier.orcidhttps://orcid.org/0000-0002-6914-6441
local.identifier.orcidhttps://orcid.org/0000-0003-2507-0243
local.identifier.orcidhttps://orcid.org/0000-0003-2719-3634
local.identifier.orcidhttps://orcid.org/0000-0001-9650-1034
local.identifier.orcidhttps://orcid.org/0000-0003-3207-4007
local.identifier.orcidhttps://orcid.org/0000-0002-1335-1040
local.identifier.orcidhttps://orcid.org/0000-0001-8812-2923
local.identifier.orcidhttps://orcid.org/0000-0002-8032-1474
local.identifier.orcidhttps://orcid.org/0000-0002-4082-1132
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1155/2021/3060375

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