Stem cell marker expression in persistent apical periodontitis

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dc.creatorCarlos Estrela
dc.creatorBrunno Santos Freitas Silva
dc.creatorJúlio A. Silva
dc.creatorFernanda Paula Yamamoto-Silva
dc.creatorDécio dos Santos Pinto-Júnior
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2024-12-10T20:36:16Z
dc.date.accessioned2025-09-09T00:17:20Z
dc.date.available2024-12-10T20:36:16Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.joen.2016.09.002
dc.identifier.issn1878-3554
dc.identifier.urihttps://hdl.handle.net/1843/78569
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Endodontics
dc.rightsAcesso Restrito
dc.subjectPeriapical periodontitis
dc.subjectThy-1 antigens
dc.subjectSoxB1 transcription factors
dc.subjectMesenchymal stem cells
dc.subjectHematopoietic stem cells
dc.subject.otherApical periodontitis
dc.subject.otherCD90
dc.subject.otherSox2
dc.subject.otherMesenchymal stem cells
dc.subject.otherPersistent apical periodontitis
dc.subject.otherProgenitor stem cells
dc.titleStem cell marker expression in persistent apical periodontitis
dc.typeArtigo de periódico
local.citation.epage68
local.citation.issue1
local.citation.spage63
local.citation.volume43
local.description.resumoIntroduction: This study evaluated the expression of CD90 (mesenchymal stem cell) and Sox2 (progenitor stem cell) markers in persistent apical periodontitis (PAP) (n = 16) and primary periapical lesions (PPLs) (n = 10). Methods: All samples were classified histologically according to the intensity of inflammatory cell infiltrate in the periapical lesion. Immunohistochemistry was used to detect CD90 and Sox2 in PAP and PPLs. The Spearman correlation coefficient and the Mann-Whitney U test were used to analyze data at the 5% significance level. Results: CD90 expression was found in mesenchymal cells and vascular endothelial cells of 68.5% of all cases of PAP. There was no correlation between CD90 expression and histopathological diagnosis (P = .053) or inflammatory cell infiltrate intensity (P = .112). CD90 staining was predominantly found in the vascular endothelial cells of 30% (n = 3) of PPLs. CD90 expression was significantly higher in PAP than in PPLs (Mann-Whitney U test, P < .05). Sox2 expression was found in all cases of PAP. Eventually, all mesenchymal and chronic inflammatory cells exhibited Sox2 expression. There was no correlation between Sox2 expression and histopathological diagnoses (P = .749), inflammatory cell infiltrate intensity (P = .510), or acute or chronic inflammatory cell infiltrate (P = .256). Sox2 expression was found in 100% of PPLs. There was no difference in Sox2 expression between PAP and PPLs (P = .477). Conclusions: Mesenchymal stem cells may contribute to the immunosuppressive environment in PAP. Additionally, distinct stem cell sources may be associated with the chronic nature of PAP as well as with the development of PPLs.
local.identifier.orcidhttps://orcid.org/0000-0002-1488-0366
local.identifier.orcidhttps://orcid.org/0000-0002-2918-7708
local.identifier.orcidhttps://orcid.org/0000-0001-6198-5155
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0099239916305842?via%3Dihub

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