Effects of angiotensin II type I receptor blocker losartan on orthodontic tooth movement

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dc.creatorAdriana Pedrosa Moura
dc.creatorIldeu Andrade Júnior
dc.creatorCarina Cristina Montalvany-Antonucci
dc.creatorSilvana Rodrigues de Albuquerque Taddei
dc.creatorCelso Martins Queiroz-Junior
dc.creatorCláudia Cristina Biguetti
dc.creatorGustavo Pompermayer Garlet
dc.creatorAnderson José Ferreira
dc.creatorMauro Martins Teixeira
dc.creatorTarcília Aparecida da Silva
dc.date.accessioned2025-06-04T20:06:16Z
dc.date.accessioned2025-09-08T23:19:14Z
dc.date.available2025-06-04T20:06:16Z
dc.date.issued2016-03
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.ajodo.2015.09.019
dc.identifier.issn1097-6752
dc.identifier.urihttps://hdl.handle.net/1843/82794
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAmerican journal of Orthodontics and Dentofacial Orthopedics
dc.rightsAcesso Restrito
dc.subjectBone remodeling
dc.subjectTooth movement techniques
dc.subjectRNA, messenger
dc.subjectRANK ligand
dc.subjectCathepsin K
dc.subjectMatrix Metalloproteinase 13
dc.subjectPeriostin
dc.subjectAlkaline phosphatase
dc.subjectCollagen type I, alpha 1 chain
dc.subjectSemaphorin-3A
dc.subjectMatrix metalloproteinase 2
dc.subjectOsteoprotegerin
dc.subjectOsteoclasts
dc.titleEffects of angiotensin II type I receptor blocker losartan on orthodontic tooth movement
dc.typeArtigo de periódico
local.citation.epage365
local.citation.issue3
local.citation.spage358
local.citation.volume149
local.description.resumoIntroduction: Drugs that block the renin-angiotensin system (RAS) are widely used for treating hypertension, heart and kidney failure, and the harmful effects of diabetes. Components of the RAS have been identified in various organs, but little is known of their effects on bone remodeling. The aim of this study was to evaluate whether the blockage of the RAS influences strain-induced bone remodeling in a model of orthodontic tooth movement. Methods: An orthodontic appliance was placed in C57BL6/J mice that were randomly divided into 2 groups: vehicle-treated mice (VH) and mice treated with losartan (an angiotensin II receptor blocker). Orthodontic tooth movement and the number of tartrate-resistant acid phosphatase-positive cells were determined by histopathologic analysis. The expression of mediators involved in bone remodeling was evaluated by quantitative real-time polymerase chain reaction. Blood pressure was measured before and during the experimental period. Results: Orthodontic tooth movement and tartrate-resistant acid phosphatase-positive cells were significantly reduced in the losartan group compared with the VH group. mRNA levels of osteoclast markers (RANK, RANKL, cathepsin K, and metalloproteinase 13) were lower in the losartan mice than in the VH group, whereas the expressions of osteoblast markers and negative regulators of bone resorption (periostin, dentin matrix protein, alkaline phosphatase, collagen 1A1, semaphorin 3A3, metalloproteinase 2, and osteoprotegerin) were higher in the VH group. Conclusions: Blockage of the RAS system decreases osteoclast differentiation and activity and, consequently, results in decreased strain-induced bone remodeling in orthodontic tooth movement.
local.identifier.orcidhttps://orcid.org/0000-0002-4977-2752
local.identifier.orcidhttps://orcid.org/0000-0002-3218-8330
local.identifier.orcidhttps://orcid.org/0000-0002-7884-7709
local.identifier.orcidhttps://orcid.org/0000-0003-4503-3108
local.identifier.orcidhttps://orcid.org/0000-0002-5071-8382
local.identifier.orcidhttps://orcid.org/0000-0002-3915-3691
local.identifier.orcidhttps://orcid.org/0000-0002-6944-3008
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0002-2921-2627
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0889540615013207?via%3Dihub

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