Brown and white adipose tissue expression of IL6, UCP1 and SIRT1 are associated with alterations in clinical, metabolic and anthropometric parameters in obese humans

Página do item simplificado
dc.creatorAntônio Sérgio Barcala Jorge
dc.creatorGislaine Cândida Batista Jorge
dc.creatorAlanna Fernandes Paraíso
dc.creatorRaissa Mendonça Porto Franco
dc.creatorLara Jhullian Tolentino Vieira
dc.creatorAline Mourão Hilzendeger
dc.creatorAndré Luiz Sena Guimarães
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorSergio Henrique Sousa Santos
dc.date.accessioned2022-08-18T10:55:55Z
dc.date.accessioned2025-09-08T23:59:56Z
dc.date.available2022-08-18T10:55:55Z
dc.date.issued2017
dc.identifier.doi10.1055/s-0042-119525
dc.identifier.issn1439-3646
dc.identifier.urihttps://hdl.handle.net/1843/44341
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofExperimental and Clinical Endocrinology & Diabetes
dc.rightsAcesso Restrito
dc.subjectObesidade
dc.subjectTecido adiposo marrom
dc.subjectInterleucina-2
dc.subjectAntropometria
dc.titleBrown and white adipose tissue expression of IL6, UCP1 and SIRT1 are associated with alterations in clinical, metabolic and anthropometric parameters in obese humans
dc.typeArtigo de periódico
local.citation.epage170
local.citation.issue3
local.citation.spage163
local.citation.volume125
local.description.resumoAim: the present study aimed to analyze the expression of IL6, UCP1 and SIRT1 in adipose tissue (WAT and BAT) in association to clinical, metabolic and anthropometric parameters in obese humans. Methods: WAT and BAT samples from obese patients (n=27) were collected. IL6, UCP1 and SIRT1 markers were measured by qRT-PCR. The association between IL6, UCP1 and SIRT1 mRNA expression and anthropometric and clinical parameters were evaluated, using appropriate statistical tests. Results: our results demonstrated that high levels of IL6 are associated with altered glucose levels in the WAT (p=0.01). In contrast, high levels of IL6 in the BAT were associated with decreased % fat (p=0.01) and fat weight (p=0.02) and increased mVO2 (p=0.02) and VO2 (p=0.02). For UCP1, a higher expression in the BAT was observed when compared to the WAT (p=0.0001). This gene expression was associated with lower values of BMI (p=0.03), % fat (P=0.02) and fat weight (P=0.02) and increased mVO2 (p=0.041) and VO2 (p=0.001). In the WAT, decreased levels of SIRT1 were associated with increased fat weight (p=0.02); in the BAT, associations were found for % fat (p=0.018) and mVO2 (p=0.03). Conclusion: these results reveal different characteristics in the biological actions between WAT and BAT in obese humans. Increased levels of IL6, UCP1 and SIRT1 in the BAT were associated with metabolic parameters improvements.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0042-119525

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG