Clinical endodontic procedures modulate periapical cytokine and chemokine gene expressions

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dc.creatorLucas Moreira Maia
dc.creatorMarcela Carvalho Espaladori
dc.creatorJulia Maria Braga Diniz
dc.creatorWarley Luciano Fonseca Tavares
dc.creatorLuciana Carla Neves de Brito
dc.creatorLeda Quércia Vieira
dc.creatorAntônio Paulino Ribeiro Sobrinho
dc.date.accessioned2022-10-21T20:18:53Z
dc.date.accessioned2025-09-09T00:29:50Z
dc.date.available2022-10-21T20:18:53Z
dc.date.issued2020-02-22
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s00784-020-03247-y
dc.identifier.issn14326981
dc.identifier.urihttps://hdl.handle.net/1843/46505
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinical Oral Investigations
dc.rightsAcesso Restrito
dc.subjectPeriapical periodontitis
dc.subjectChemokines
dc.subjectCytokines
dc.subjectInterleukins
dc.subject.otherApical periodontitis
dc.subject.otherCytokine and chemokine
dc.subject.otherIL-9
dc.subject.otherInterleukin
dc.subject.otherTH9
dc.titleClinical endodontic procedures modulate periapical cytokine and chemokine gene expressions
dc.typeArtigo de periódico
local.citation.epage3697
local.citation.spage3691
local.citation.volume22
local.description.resumoObjectives: To identify the gene expression of the cytokines IL-9, TNF-α, IL-1, INF-γ, IL-17A, and IL-10 and the chemokines CCL-2/MCP-1 and CCR-6 in the periapical fluid of human root canal infections. Materials and methods: Twenty samples were collected immediately and 7 days after the cleaning and shaping procedures (after reducing the intracanal microbial load) in an attempt to characterize the expression of these genes. The endogenous expression levels of cytokines and chemokines were analyzed by real-time polymerase chain reaction. The Shapiro-Wilk and the Wilcoxon tests analyzed data. Results: Significantly higher levels of the IL-9, INF-γ, TNF-α, IL-1, and IL-10 markers on day 7 were observed compared with day 0 (p < 0.05). However, IL-17A and the chemokines CCL-2/MCP-1 and CCR-6 did not show a significant difference in mRNA expression when comparing both timepoints (p > 0.05). Conclusions: The clinical variation of the periapical immune status after endodontic therapy suggests that the cytokine and chemokine-mediated pro-inflammatory response appears to be modulated in an IL-10/IL-9-dependent manner. Clinical relevance: Few studies have investigated the role of Th9 cells in periapical lesions. IL-9 presents exciting plasticity, performing immunosuppressive actions, and it is also capable of changing their phenotype in the presence of IL-17. Hence, it is relevant to investigate its role in the context of the known mediators involved the periapical immune process
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s00784-020-03247-y

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