Expression of cell cycle proteins according to HPV status in oral squamous cell carcinoma affecting young patients: a pilot study

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dc.creatorMarisol Miranda-Galvis
dc.creatorJucelino Freitas Jardim
dc.creatorEstela Kaminagakura Tango
dc.creatorAlan Roger dos Santos-Silva
dc.creatorFelipe Paiva Fonseca
dc.creatorOslei Paes de Almeida
dc.creatorMárcio Ajudarte Lopes
dc.creatorClóvis Antonio Lopes Pinto
dc.creatorLuiz Paulo Kowalski
dc.date.accessioned2023-10-17T19:47:41Z
dc.date.accessioned2025-09-09T00:49:06Z
dc.date.available2023-10-17T19:47:41Z
dc.date.issued2018-04
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2018.01.003
dc.identifier.issn22124403
dc.identifier.urihttps://hdl.handle.net/1843/59559
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsAcesso Aberto
dc.subjectProteins
dc.subjectCarcinoma
dc.subjectHuman papillomavirus viruses
dc.subjectImmunohistochemistry
dc.subjectSurvival
dc.subjectDNA
dc.subject.otherfao clinica busca dia 09 do 09 2023 assunto proteina
dc.titleExpression of cell cycle proteins according to HPV status in oral squamous cell carcinoma affecting young patients: a pilot study
dc.typeArtigo de periódico
local.citation.epage325
local.citation.issue4
local.citation.spage317
local.citation.volume125
local.description.resumoObjective: Tobacco and alcohol consumption are considered the main risk factors for oral squamous cell carcinoma (OSCC); however, the role of these factors in patients younger than 40 years is controversial, so it has been suggested that genomic instability and high-risk human papillomavirus (HR-HPV) infection may be contributing factors to oral carcinogenesis at a young age. Therefore, the aim of this study was to evaluate the immunoexpression of cell cycle proteins according HPV status in OSCC affecting young patients. Methods: A tissue microarray construction based on 34 OSCC samples from young patients (<40 years old) was subjected to immunohistochemical reactions for Ki67, cyclin D1, C-ErbB2, p21, Myc, epidermal growth factor receptor, p53, and p16 antibodies. Results: The clinicopathologic features and the immunoexpression of all tested proteins were similar in both groups. Patients with HPV-related OSSC tended to have better cancer-specific survival (CSS; 39% vs 60% 5-y CSS), and overall survival (OS; 29.2% vs 60% 5-year OS). However, this difference was not statistically significant. Conclusion: No significant difference exists in the expression of cell cycle proteins studied between HR-HPV DNA-positive and HR-HPV DNA-negative OSCC affecting young patients.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440318300397?via%3Dihub

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