Nicorandil inhibits mechanical allodynia in the model of neuropathic pain induced by paclitaxel by activating opioidergic and serotoninergic mechanisms

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dc.creatorMarcela Ìsis Morais
dc.creatorAlysson Vinícius Braga
dc.creatorFelipe Fernandes Rodrigues
dc.creatorIvo Souza Ferraz de Melo
dc.creatorÂngelo de Fátima
dc.creatorMárcio de Matos Coelho
dc.creatorRenes de Resende Machado
dc.date.accessioned2024-03-06T20:19:51Z
dc.date.accessioned2025-09-08T23:22:43Z
dc.date.available2024-03-06T20:19:51Z
dc.date.issued2017
dc.format.mimetypepdf
dc.identifier.urihttps://hdl.handle.net/1843/65385
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Congress of Pharmacology and Experimental Therapeutics
dc.rightsAcesso Aberto
dc.subjectAgentes antiinflamatórios
dc.subjectDor neuropática
dc.subjectNicorandil
dc.subject.otherEndocannabinoids
dc.subject.otherAnti-inflammatory
dc.titleNicorandil inhibits mechanical allodynia in the model of neuropathic pain induced by paclitaxel by activating opioidergic and serotoninergic mechanisms
dc.typeArtigo de evento
local.citation.issue49
local.citation.spage22
local.description.resumoNeuropathic pain is a chronic disorder usually associated with central or peripheral nervous system lesions or diseases. A myriad of neurochemical mechanisms may contribute to establishment of neuropathic pain, thus contributing to the refractoriness to the traditional analgesic therapies. As low as 25% of the patients exhibiting neuropathic pain get a relief greater than 50% after using the available analgesic medicines. Nicorandil, a drug that releases nitric oxide (NO) and opens ATP sensitive potassium channels, has been approved in some countries to treat patients with angina pectoris. The activity of nicorandil in models of nociceptive and inflammatory pain has been recently demonstrated, thus justifying additional investigations in models of neuropathic pain. Methods: The effect induced by nicorandil (50, 100 or 150 mg/kg, per os-p.o.) on the mechanical allodynia induced by paclitaxel (2 mg/kg, 2 mL/kg, intraperitoneal-i.p.) in male Swiss mice (25-30 g) was evaluated. To investigate putative mechanisms mediating the antinocicepive activity of nicorandil in the model of neuropathic pain induced by paclitaxel, opioidergic (naltrexone 5 or 10 mg/kg, i.p.) and serotonergic (cyproheptadine 5 or 10 mg/kg, i.p.) antagonists and an ATP-dependent potassium channel blocker (glibenclamide, 20 or 40 mg/kg, p.o.) were used. Nicorandil was administered twice (8 mL/kg, p.o.), within a two hour interval. Results: Nicorandil inhibited the mechanical allodynia induced by paclitaxel when administered once or twice in the seventh or fourteenth day after first injection of paclitaxel. A greater antinociceptive effect was observed when nicorandil was administered twice within two hours interval. Naltrexone and cyproheptadine, but not glibenclamide, attenuated the antinociceptive effect induced by nicorandil. Conclusion: The results demonstrate that nicorandil exhibits antinociceptive activity in the model of neuropathic pain induced by paclitaxel. This activity may be mediated by activation of opioidergic and serotonergic receptors, but not ATP-sensitive potassium channels. The results indicate that nicorandil may represent a pharmacotherapeutic strategy in the treatment of patients with neuropathic pain and justify additional preclinical and clinical assays aiming to evaluate its potential use as an analgesic drug.
local.identifier.orcidhttps://orcid.org/0000-0003-2344-5590
local.identifier.orcidhttps://orcid.org/0000-0001-7732-9988
local.identifier.orcidhttps://orcid.org/0000-0002-1284-1195
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://sbfte.org.br/congressos-anteriores/congresso-2017/

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