Uniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell line

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dc.creatorDiego Fernando Suárez Peñaranda
dc.creatorAna Delia Pinzón García
dc.creatorRubén Dario Sinisterra Millán
dc.creatorAnderson Dussan Cuenca
dc.creatorFredy Mesa
dc.creatorSandra Ramírez-Clavijo
dc.date.accessioned2024-01-26T18:51:46Z
dc.date.accessioned2025-09-08T23:44:24Z
dc.date.available2024-01-26T18:51:46Z
dc.date.issued2022
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/nano12193348
dc.identifier.issn2079-4991
dc.identifier.urihttps://hdl.handle.net/1843/63434
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNanomaterials
dc.rightsAcesso Aberto
dc.subjectMamas - Câncer
dc.subjectTecnologia de liberação controlada
dc.subjectAgentes antineoplásicos
dc.subject.otherNanofiber
dc.subject.otherCurcumin
dc.subject.otherTamoxifen
dc.subject.otherBreast cancer
dc.subject.otherElectrospinning
dc.subject.otherMCF-7
dc.titleUniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell line
dc.typeArtigo de periódico
local.citation.issue19
local.citation.volume12
local.description.resumoBreast cancer is the second cause of cancer death in women worldwide. The search for therapeutic and preventive alternatives has increased in recent years. One synthetic drug for patients with hormone receptor-positive tumours is tamoxifen citrate (TMX). Curcumin (Cur) is a natural compound that is being tested. Both were coupled with nanoscale-controlled and sustained release systems to increase the effectiveness of the treatment and reduce adverse effects. We produced a controlled release system based on uniaxial and coaxial polymeric nanofibers of polycaprolactone (PCL), alginate (Alg) and gelatine (Gel) for the transport and release of TMX and Cur, as a new alternative to breast cancer treatment. Nanofibers combining PCL–Alg and PCL–Gel were fabricated by the electrospinning technique and physicochemically characterised by thermal analysis, absorption spectroscopy in the infrared region and X-ray diffraction. Morphology and size were studied by scanning electron microscopy. Additionally, the release profile of TMX and Cur was obtained by UV-Vis spectroscopy. Additionally, the cytotoxic effect on breast cancer cell line MCF7 and peripheral-blood mononuclear cells (PBMCs) from a healthy donor were evaluated by a Resazurin reduction assay. These assays showed that PCL–TMX nanofiber was highly toxic to both cell types, while PCL–Cur was less toxic.
local.identifier.orcidhttps://orcid.org/0000-0002-3139-4239
local.identifier.orcidhttps://orcid.org/0000-0002-8876-4907
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.identifier.orcidhttps://orcid.org/0000-0001-5355-2640
local.identifier.orcidhttps://orcid.org/0000-0003-0920-7748
local.identifier.orcidhttps://orcid.org/0000-0003-0336-5614
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2079-4991/12/19/3348

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