Klotho dysfunction: a pathway linking the aging process to bipolar disorder?

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dc.creatorIzabela Guimarães Barbosa
dc.creatorNatalia Pessoa Rocha
dc.creatorGokay Alpak
dc.creatorErica Leandro Marciano Vieira
dc.creatorRodrigo Barreto Huguet
dc.creatorFabio Lopes Rocha
dc.creatorBreno Satler de Oliveira Diniz
dc.creatorAntonio Lucio Teixeira
dc.date.accessioned2023-07-17T19:09:02Z
dc.date.accessioned2025-09-09T01:34:24Z
dc.date.available2023-07-17T19:09:02Z
dc.date.issued2017-08-09
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.jpsychires.2017.08.007
dc.identifier.issn00223956
dc.identifier.urihttps://hdl.handle.net/1843/56456
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Psychiatric Research
dc.rightsAcesso Restrito
dc.subjectEnvelhecimento
dc.subjectTranstorno Bipolar
dc.subjectProteínas Klotho
dc.subjectTranstornos do Humor
dc.subject.otherAging
dc.subject.otherBipolar disorder
dc.subject.otherInflammation
dc.subject.otherKlotho
dc.subject.otherMood disorder
dc.subject.otherMood disorder
dc.titleKlotho dysfunction: a pathway linking the aging process to bipolar disorder?
dc.typeArtigo de periódico
local.citation.epage88
local.citation.issue2017
local.citation.spage80
local.citation.volume95
local.description.resumoAim: Although accelerated aging profile has been described in bipolar disorder (BD), the biology linking BD and aging is still largely unknown. Reduced levels and/or activity of a protein named Klotho is associated with decreased life span, premature aging and occurrence of age-related diseases. Therefore,this study was designed to evaluate plasma levels of Klotho in BD patients and controls. Methods: Forty patients with type 1 BD and 30 controls were enrolled in this study. After clinical evaluation, peripheral blood samples were drawn and plasma levels of Klotho were measured using enzyme-linked immunosorbent assay. Results: Patients with BD and controls presented similar age and sex distribution. The mean ± SD length of illness was 24.00 ± 12.75 years. BD patients presented increased frequency of clinical comorbidities in comparison with controls, mainly arterial hypertension, diabetes mellitus, and hypothyroidism. Both patients with BD in remission and in mania exhibited increased plasma levels of Klotho in comparison with controls. There was no significant difference between patients in mania and patients in remission regarding the levels of Klotho. Conclusion: Klotho-related pathway is altered in BD. Contrary to our original hypothesis, our sample of patients with BD presented increased plasma levels of Klotho in comparison with controls. Elevated levels of Klotho in long-term BD patients may be associated with the disorder progression. Further studies are needed to better understand the role of Klotho in BD and other mood disorders
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0022395617304351

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