HER-2 and EGFR mRNA expression and its relationship with Versican in malignant matrix-producing tumors of the canine mammary gland

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dc.creatorKarine Araújo Damasceno
dc.creatorEnio Ferreira
dc.creatorAlessandra Estrela da Silva Lima
dc.creatorConrado de Oliveira Gamba
dc.creatorFernanda Freitas Miranda
dc.creatorMariana Rezende Alves
dc.creatorRafael Malagoli Rocha
dc.creatorAndré Luís Branco de Barros
dc.creatorGeovanni Dantas Cassali
dc.date.accessioned2022-03-09T18:59:07Z
dc.date.accessioned2025-09-09T00:36:04Z
dc.date.available2022-03-09T18:59:07Z
dc.date.issued2016-08-04
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0160419
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1843/39905
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPlos One
dc.rightsAcesso Aberto
dc.subjectNeoplasias mamárias animais
dc.subjectVersicanas
dc.subjectReceptores de superfície celular
dc.subjectHibridização in situ
dc.subjectGenes ErbB
dc.subjectTumor misto maligno
dc.subjectMetástase neoplásica
dc.titleHER-2 and EGFR mRNA expression and its relationship with Versican in malignant matrix-producing tumors of the canine mammary gland
dc.typeArtigo de periódico
local.citation.epage14
local.citation.issue8
local.citation.spage1
local.citation.volume11
local.description.resumoVersican expression promotes tumor growth by destabilizing focal cell contacts, thus impeding cell adhesion and facilitating cell migration. It not only presents or recruits molecules to the cell surface, but also modulates gene expression levels and coordinates complex signal pathways. Previously, we suggested that the interaction between versican and human epidermal growth factor receptors may be directly associated with tumor aggressiveness. Thus, the expression of EGFR and HER-2 in these neoplasms may contribute to a better understanding of the progression mechanisms in malignant mammary tumors. The purpose of this study was to correlate the gene and protein expressions of EGFR and HER2 by RNA In Situ Hybridization (ISH) and immunohistochemistry (IHC), respectively, and their relationship with the versican expression in carcinomas in mixed tumors and carcinosarcomas of the canine mammary gland. The results revealed that EGFR mRNA expression showed a significant difference between in situ and invasive carcinomatous areas in low and high versican expression groups. Identical results were observed in HER-2 mRNA expression. In immunohistochemistry analysis, neoplasms with low versican expression. showed greater EGFR immunostaining in the in situ areas than in invasive areas, even as the group presenting high versican expression displayed greater EGFR and HER-2 staining in in situ areas. Significant EGFR and HER-2 mRNA and protein expressions in in situ carcinomatous sites relative to invasive areas suggest that these molecules play a role during the early stages of tumor progression.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160419

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