Inhibition of GATA3, ABCB1, and TYR by gallic acid: a real-world approach to uncovering a preventive agent against oral squamous cell carcinoma development

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dc.creatorOsvaldo Sena Guimarães
dc.creatorLílian Mendes Borburema Cangussu
dc.creatorLorena dos Reis Pereira Queiroz
dc.creatorEliane Macedo Sobrinho Santos
dc.creatorMarcela Gonçalves de Souza
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorLucyana Conceição Farias
dc.creatorSérgio Henrique Sousa Santos
dc.creatorMarcos Flávio Silveira Vasconcelos D'Angelo
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2024-10-10T19:20:43Z
dc.date.accessioned2025-09-08T23:50:36Z
dc.date.available2024-10-10T19:20:43Z
dc.date.issued2023-12
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.genrep.2023.101840
dc.identifier.issn2452-0144
dc.identifier.urihttps://hdl.handle.net/1843/77365
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofGene Reports
dc.rightsAcesso Restrito
dc.subjectCabeça - Câncer
dc.subjectPescoço - Câncer
dc.subjectCarcinoma de células escamosas
dc.subjectÁcido gálico
dc.subjectPolifenóis
dc.subjectBioinformática
dc.titleInhibition of GATA3, ABCB1, and TYR by gallic acid: a real-world approach to uncovering a preventive agent against oral squamous cell carcinoma development
dc.typeArtigo de periódico
local.citation.spage101840
local.citation.volume33
local.description.resumoObjective: this study aimed to the efficacy of gallic acid (GA) as a prospective prophylactic agent against the onset of oral squamous cell carcinoma (OSCC). Methods: we conducted bioinformatic analyses to identify the molecular targets of GA. Subsequently, we employed the 4NQO-induced animal model to evaluate the therapeutic potential of GA in OSCC. Results: our analysis unveiled that only three genes, ABCB1, GATA3, and SERPINE1, were associated with survival outcomes in OSCC patients. Reduced expressions of ABCB1 and GATA3 correlated with hazard ratios of 1.53 and 2.06, respectively, for mortality, while elevated SERPINE1 expression carried a 1.42-fold increased risk of death in OSCC patients. Molecular docking simulations underscored the robust affinity between GA and these genes, revealing binding energies of −6.0 kcal/mol for ABCB1, − 6.1 kcal/mol for GATA3, and −5.9 kcal/mol for SERPINE1. Furthermore, GA treatment demonstrated statistically significant reductions in the histopathological grade of 4NQO-induced lesions (p = 0.006) and mitigated liver (p < 0.001) and kidney (p < 0.001) toxicity associated with 4NQO exposure. Conclusion: the current study highlights GA as a promising contender for OSCC prevention. Mainly, GA targets critical genes such as ABCB1, GATA3, and SERPINE1, substantially impacting patient survival. Furthermore, GA administration mitigates 4NQO-induced toxicity, indicating its potential to improve animal survival by reducing lesion severity. These findings carry significant implications for OSCC research and potential clinical applications.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2452014423001024

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