Evidence of hypoglycemic, lipid-lowering and hepatoprotective effects of the bixin and bixin: β-CD inclusion compound in high-fat-fed obese mice

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dc.creatorAna Delia Pinzón García
dc.creatorLaura Alejandra Ariza Orellano
dc.creatorMarcela Guimarães Takahashi de Lazari
dc.creatorPaula Peixoto Campos
dc.creatorMaría Esperanza Cortés Segura
dc.creatorRubén Dario Sinisterra Millán
dc.date.accessioned2023-11-24T15:25:57Z
dc.date.accessioned2025-09-08T23:32:48Z
dc.date.available2023-11-24T15:25:57Z
dc.date.issued2018-10
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2018.06.144
dc.identifier.issn1950-6007
dc.identifier.urihttps://hdl.handle.net/1843/61352
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.rightsAcesso Restrito
dc.subjectCarotenoides
dc.subjectDiabetes
dc.subjectObesidade - Tratamento
dc.subjectDegeneração gordurosa
dc.subjectAgentes hipoglicemicos
dc.subjectHipolipemiantes
dc.subjectMatéria médica vegetal
dc.subjectCiclodextrinas
dc.subject.otherBixin
dc.subject.otherInclusion compound
dc.subject.otherDiabetes type II
dc.subject.otherObesity
dc.subject.otherSteatosis
dc.titleEvidence of hypoglycemic, lipid-lowering and hepatoprotective effects of the bixin and bixin: β-CD inclusion compound in high-fat-fed obese mice
dc.typeArtigo de periódico
local.citation.epage372
local.citation.spage363
local.citation.volume106
local.description.resumoAssociations between obesity, diabetes type II, and steatosis have long been recognized. However, a pharmacotherapy that acts in a multifactorial manner controlling the interactions between these conditions is not available. A variety of natural plants, functional fatty acids, and other natural dietary compounds have been used in various anti-obesity products. We investigated the effects of oral administration of an antioxidant carotenoid pigment Bixin and Bixin: β-Cyclodextrin in an obese murine model. C57BL/6 male mice (4–5 weeks) received standard diet (2.18 kcal per 1 g) (CT) and high-fat diet (4.38 kcal per 1 g) (CT/OB, BIX and BIX/βCD) (n = 10 per group). After 16 weeks, the BIX and BIX/βCD were treated by gavage (100 μL day-1) for six weeks, with water (CT and CT/OB groups) and (50 mg kg-1 day-1), Bixin (BIX group) or Bix: β-CD (BIX/βCD). Body weight, Lee's Index, adiposity, CHT, TG, CHT/HDL-c, glucose levels (metabolic markers) and, liver markers (AST and ALT) were determined. All metabolic and liver parameters exhibited down-regulation after oral administration of BIX and BIX/βCD. Particularly relevant was Lee’s Index and adiposity in BIX- and BIX/βCD-treated groups (339.18 g/cm -BIX and 327.58 g/cm -BIX/βCD vs. 360.68 g/cm -CT/OB animals), this finds associated with the insulin sensitivity test, showed a clear association between reduction of adipose tissue and decrease of peripherical insulin resistant. In conclusion, our study suggested that the oral administration of the Bixin and Bix: β-CD inclusion compound improved the metabolic parameters evaluate in obese mice, being more palatable and hepatoprotective.
local.identifier.orcidhttps://orcid.org/0000-0002-8876-4907
local.identifier.orcidhttps://orcid.org/0000-0003-1509-8488
local.identifier.orcidhttps://orcid.org/0000-0002-9912-9044
local.identifier.orcidhttps://orcid.org/0000-0003-2016-2210
local.identifier.orcidhttps://orcid.org/0000-0002-0560-8491
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0753332218309703

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