Acute oral treatment with resveratrol and Lactococcus Lactis Subsp. Lactis decrease body weight and improve liver proinflammatory markers in C57BL/6 mice

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dc.creatorKeila Lopes Mendes
dc.creatorDeborah de Farias Lelis
dc.creatorDaniela Fernanda de Freitas
dc.creatorLuiz Henrique da Silveira
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.creatorJanaína Ribeiro de Oliveira
dc.creatorMariléia Chaves Andrade
dc.creatorSérgio Avelino Mota Nobre
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2023-05-04T11:12:12Z
dc.date.accessioned2025-09-08T23:08:03Z
dc.date.available2023-05-04T11:12:12Z
dc.date.issued2021-02-14
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1007/s11033-021-06190-7
dc.identifier.issn1573-4978
dc.identifier.urihttps://hdl.handle.net/1843/52788
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMolecular Biology Reports
dc.rightsAcesso Restrito
dc.subjectPolifenóis
dc.subjectInflamação
dc.subjectFígado - Doenças
dc.titleAcute oral treatment with resveratrol and Lactococcus Lactis Subsp. Lactis decrease body weight and improve liver proinflammatory markers in C57BL/6 mice
dc.typeArtigo de periódico
local.citation.epage1734
local.citation.spage1725
local.citation.volume48
local.description.resumoThe present study aimed to evaluate the effects of resveratrol, a nutraceutical polyphenol, and Lactococcus lactis (bacteria probiotic), on metabolic parameters and hepatic proinflammatory markers expression. C57BL/6 mice were divided into 4 groups: Standard (ST), Lactococcus lactis (LL), Resveratrol (RSV), and Lactococcus lactis plus resveratrol (LL + RSV). Lactococcus lactis and resveratrol were administered by orogastric gavage. Blood parameters were assessed (total cholesterol, triglycerides, ALT and AST). IL-6 mRNA expression was evaluated by Real-time PCR and TNF-α protein expression was assessed by immunohistochemistry. The main findings showed that resveratrol and Lactococcus lactis association decreased body weight, aspartate aminotransferase and total cholesterol levels. LL and LL + RSV decreased triglycerides levels and IL-6 and TNF-α expression. These results open a perspective of using resveratrol and Lactococcus lactis to improve metabolic parameters and Lactococcus lactis in preventing inflammation and the hepatic diseases development.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s11033-021-06190-7

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