High prevalence of functional dyspepsia in nonalcoholic fatty liver disease: a cross-sectional study

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dc.creatorÉrika Cristina Lima
dc.creatorClaudia Alves Couto
dc.creatorMaria do Carmo Friche Passos
dc.creatorSilvia Marinho Ferolla
dc.creatorRaissa Soares Neves da Costa
dc.creatorQuelson Coelho Lisboa
dc.creatorLucas Ismael Dias Pereira
dc.creatorMateus Jorge Nardelli
dc.creatorVitor Nunes Arantes
dc.creatorTeresa Cristina de Abreu Ferrari
dc.date.accessioned2023-11-06T21:11:21Z
dc.date.accessioned2025-09-09T00:40:35Z
dc.date.available2023-11-06T21:11:21Z
dc.date.issued2022
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1516-3180.2021.0015.r1.14062021
dc.identifier.issn1516-3180
dc.identifier.urihttps://hdl.handle.net/1843/60539
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofSão Paulo Medical Journal
dc.rightsAcesso Aberto
dc.subjectGastroenteropatias
dc.subjectHepatopatia gordurosa não alcoólica
dc.subjectDispepsia
dc.subjectObesidade
dc.subjectDiabetes Mellitus
dc.subject.otherFunctional gastrointestinal disorders
dc.subject.otherNAFLD
dc.subject.otherIndigestion
dc.subject.otherBody weight
dc.titleHigh prevalence of functional dyspepsia in nonalcoholic fatty liver disease: a cross-sectional study
dc.typeArtigo de periódico
local.citation.epage206
local.citation.issue2
local.citation.spage199
local.citation.volume140
local.description.resumoBACKGROUND: Gastrointestinal (GI) symptoms are frequent complaints from individuals with nonalcoholic fatty liver disease (NAFLD). Dyspepsia is a universal clinical symptom and is among the most common GI complaints observed in the general population, but its prevalence in the population with NAFLD has not been previously investigated. OBJECTIVE: To compare the prevalence of functional dyspepsia (FD) between patients with NAFLD and controls without liver disease. DESIGN AND SETTING: Cross-sectional study at the Outpatient Liver Clinic, University Hospital, Belo Horizonte, Brazil. METHODS: We included 96 NAFLD patients and 105 controls without liver disease. All participants were assessed for GI symptoms in accordance with the Rome III criteria. Evaluation methods included a questionnaire for FD (validated in Brazil), laboratory tests and upper GI endoscopy. RESULTS: Mean age and sex were similar between the groups. The NAFLD group presented higher frequency of proton-pump inhibitor usage (31.3% vs 4.8%; P < 0.001) and prevalence of FD (25.0% versus 12.4%; P = 0.021). The symptom frequencies were as follows: postprandial distress, 22.9% versus 11.4% (P = 0.030); postprandial fullness, 18.8% versus 10.5% (P = 0.095); early satiation, 8.3% versus 5.7% (P = 0.466); and epigastric pain or burning, 18.8% versus 5.7% (P = 0.004), in NAFLD patients and controls, respectively. Multivariate analysis demonstrated that female sex (odds ratio, OR 6.97; 95% confidence interval, CI: 1.51-32.12; P = 0.013) and NAFLD diagnosis (OR 2.45; 95% CI: 1.14-5.27; P = 0.021) were independently associated with FD occurrence. CONCLUSION: FD occurs more frequently in individuals with NAFLD than in controls without hepatic disease.
local.identifier.orcidhttps://orcid.org/0000-0001-9459-2294
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/spmj/a/FFW8kwCpLVQngqXQCSdQPQS/?lang=en

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