The combined polymorphisms of interleukin-6-174GG genotype and interleukin-10 ATA haplotype are associated with a poor quality of life in patients with chronic hepatitis C

Página do item simplificado
dc.creatorDiego Alves Vieira
dc.creatorFabrício Freire de Melo
dc.creatorDulciene Maria de Magalhães Queiroz
dc.creatorLuciana Diniz Silva
dc.creatorLuciana Rodrigues da Cunha
dc.creatorCliviany Borges da Silva
dc.creatorMaria Thereza Bastos Almeida
dc.creatorAdriana Dias Gomes
dc.creatorCésar Lúcio Lopes de Faria
dc.creatorRosângela Teixeira
dc.creatorFernando Silva Neves
dc.creatorGifone Aguiar Rocha
dc.date.accessioned2023-07-12T23:04:50Z
dc.date.accessioned2025-09-09T01:30:14Z
dc.date.available2023-07-12T23:04:50Z
dc.date.issued2019-02-07
dc.format.mimetypepdf
dc.identifier.doi10.1007/s11136-019-02129-5
dc.identifier.issn09629343
dc.identifier.urihttps://hdl.handle.net/1843/56161
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofQuality of Life Research
dc.rightsAcesso Restrito
dc.subjectHepatite C Crônica
dc.subjectQualidade de Vida
dc.subjectInterleucina-6
dc.subjectInterleucina-10
dc.subject.otherChronic hepatitis C
dc.subject.otherHealth-related quality of life
dc.subject.otherIL6 gene polymorphism
dc.subject.otherIL10 gene polymorphism
dc.titleThe combined polymorphisms of interleukin-6-174GG genotype and interleukin-10 ATA haplotype are associated with a poor quality of life in patients with chronic hepatitis C
dc.typeArtigo de periódico
local.citation.epage1542
local.citation.issue6
local.citation.spage1531
local.citation.volume28
local.description.resumoPurpose Chronic hepatitis C (CHC) is associated with a decreased health-related quality of life (HRQOL). More recent studies have pointed toward a genetic basis of patient-reported quality of life outcomes. Taking into account that the influence of single-nucleotide polymorphisms (SNPs) on the HRQOL of CHC patients has not been studied, we investigated the combined IL10-1082G/A, − 819C/T, and − 592C/A SNPs, and IL6-174G/C SNP. We also evaluated the association between demo graphic, clinical, psychiatric, virological, and genetic variables with domains and summaries of HRQOL in CHC patients. Methods 132 consecutive CHC patients and 98 controls underwent psychiatric evaluation by using the Mini International Neuropsychiatric Interview. HRQOL was assessed by a generic questionnaire, the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and by the specific Liver Disease Quality of Life Questionnaire (LDQOL). IL6 and IL10 poly morphisms were evaluated by Taqman SNP genotyping assay. Multivariate analysis was used to evaluate the associations. Results Major depressive disorder was associated with lower SF-36 and LDQOL scores in seven and ten domains, respec tively. Diabetes and hypertension were also associated with reduced HRQOL. CHC patients carrying the combination of IL10 ATA haplotype/IL6-GG genotype had lower scores in the SF-36—physical functioning domain, and reduced scores in the LDQOL effects of liver disease on activities of daily living, quality of social interaction, and sexual function domains than the non-carriers of the combined haplotype/genotype.Conclusion This is the first study to demonstrate that combined IL6 high-producer GG genotype and IL10 low-producer ATA haplotype is associated with poorer HRQOL in CHC patients.
local.identifier.orcidhttps://orcid.org/0000-0003-2757-1375
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s11136-019-02129-5

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG