Association between dyslipidemia and CCL2 in patients undergoing hemodialysis

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dc.creatorWander Valadares de Oliveira Junior
dc.creatorAna Paula Ferreira Silva
dc.creatorRoberta Carvalho de Figueiredo
dc.creatorKarina Braga Gomes
dc.creatorAna Cristina Simões e Silva
dc.creatorLuci Maria Sant'Ana Dusse
dc.creatorDanyelle Romana Alves Rios
dc.date.accessioned2026-01-23T19:02:19Z
dc.date.issued2020-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.cyto.2019.154858
dc.identifier.issn1096-0023
dc.identifier.urihttps://hdl.handle.net/1843/1485
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCytokine
dc.rightsAcesso restrito
dc.subjectDoença renal
dc.subject.otherMCP-1/CCL2
dc.subject.otherDislipidemia
dc.subject.otherFator de risco cardiovascular
dc.subject.otherDoença renal crônica
dc.subject.otherHemodiálise
dc.titleAssociation between dyslipidemia and CCL2 in patients undergoing hemodialysis
dc.typeArtigo de periódico
local.citation.epage6
local.citation.spage1
local.citation.volume125
local.description.resumoHemodialysis (HD) is associated with high risk for cardiovascular diseases including acute myocardial infarction, stroke and congestive heart failure. C-C Motif Chemokine Ligand 2 (CCL2), also known monocyte chemotactic protein-1 (MCP-1) can be produced by a variety of cells, reaching increased levels in dyslipidemic chronic kidney disease (CKD) patients undergoing HD treatment. The main of this study was to evaluate the association between of CCL2 plasma levels and dyslipidemia in CKD patients undergoing HD. Methods A cross-sectional study enrolled 160 Brazilian HD patients. CCL2 plasma levels were measured by capture ELISA. The association between CCL2 levels and dyslipidemia was investigated using linear regression, adjusted for classic and non-classical CVD risk factors. Results A significant association was observed between CCL2 levels and dyslipidemia (P = 0.029), even after adjustment for possible confounding variables, such as age, gender, body mass index, diabetes mellitus, HD time, urea pre-hemodialysis and interdialytic weight gain (P = 0.045). Conclusion Our findings show that CCL2 levels are associated with dyslipidemia, which suggests a role of this cytokine in the pathogenesis of cardiovascular disease in HD patients. A better understanding of this pathogenesis could contribute to the discovery of new therapeutic targets that would reduce cardiovascular complications in these patients.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.subject.cnpqCIENCIAS DA SAUDE
local.url.externahttps://www.sciencedirect.com/science/article/pii/S104346661930287X

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