Prognostic factors associated with death from visceral leishmaniasis: a case-control study in Brazil

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dc.creatorMaria Helena Franco Morais
dc.creatorStefanne Aparecida Gonçalves
dc.creatorHelen Maria de Oliveira Ramos Lopes
dc.creatorFrederico Figueiredo Amâncio
dc.creatorThais Almeida Marques da Silva
dc.creatorCarlos Maurício Figueiredo Antunes
dc.creatorFernanda do Carmo Magalhães
dc.creatorMariângela Carneiro
dc.date.accessioned2023-03-08T00:31:23Z
dc.date.accessioned2025-09-08T23:36:16Z
dc.date.available2023-03-08T00:31:23Z
dc.date.issued2020-02-29
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://doi.org/10.1093/trstmh/traa010
dc.identifier.issn1878-3503
dc.identifier.urihttps://hdl.handle.net/1843/50726
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofTransactions of the Royal Society of Tropical Medicine and Hygiene
dc.rightsAcesso Restrito
dc.subjectEstudos de Casos e Controles
dc.subjectLeishmaniose Visceral
dc.subjectPrognóstico
dc.titlePrognostic factors associated with death from visceral leishmaniasis: a case-control study in Brazil
dc.typeArtigo de periódico
local.citation.epage354
local.citation.issue5
local.citation.spage346
local.citation.volume114
local.description.resumoBackground: The aim of this study was to identify the prognostic factors associated with death from visceral leishmaniasis (VL) considering the clinical evolution of patients through a case-control study. Methods: We randomly selected 180 cases (death caused by VL) and 180 controls (cured) from Belo Horizonte's hospitals in Brazil, according to data found in the patients' medical records. Five models of multivariate logistic regression were performed following the chronological order of the variables between the onset of the symptoms and evolution of the VL cases. Results: Considering the multivariate models and the stages of clinical evolution of VL, the prognostic factors associated with death are: age >60 y, minor hemorrhagic phenomena, increased abdominal volume, jaundice, dyspnea, malnutrition, TB, billirubin >2 mg/dL, Aspartate Aminotransferase (AST) or Alanine Aminotransferase (ALT) >100 U/L, leukocytes >7000/mm3, hemoglobin <7 g/dL, platelets <50 000/mm3 and infection without defined focus and bleeding. Conclusions: Knowledge regarding the prognostic factors associated with death from VL in different stages of the disease in large Brazilian urban centers such as Belo Horizonte may help optimize patient management strategies and contribute to reduce the high fatality rates in these cities.
local.identifier.orcidhttps://orcid.org/0000-0002-5042-2004
local.identifier.orcidhttps://orcid.org/0000-0003-3286-8683
local.identifier.orcidhttps://orcid.org/0000-0002-5732-7173
local.identifier.orcidhttps://orcid.org/0000-0002-6025-2774
local.identifier.orcidhttps://orcid.org/0000-0002-9390-7714
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE PARASITOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/trstmh/article/114/5/346/5766439

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